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Titolo:
EFFECT OF SALMON-CALCITONIN ON IN-VITRO OPIOID WITHDRAWAL
Autore:
ALFARO MJ; FERNANDEZ B; GOICOECHEA C; MARTIN MI;
Indirizzi:
UNIV COMPLUTENSE MADRID,FAC MED,DEPT FARMACOL E-28040 MADRID SPAIN UNIV COMPLUTENSE MADRID,FAC MED,DEPT FARMACOL E-28040 MADRID SPAIN
Titolo Testata:
Japanese Journal of Pharmacology
fascicolo: 1, volume: 75, anno: 1997,
pagine: 101 - 104
SICI:
0021-5198(1997)75:1<101:EOSOIO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
INVOLVEMENT; DEPENDENCE; MORPHINE; INVITRO;
Keywords:
MORPHINE WITHDRAWAL; OPIOID ABSTINENCE; CALCITONIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
M.J. Alfaro et al., "EFFECT OF SALMON-CALCITONIN ON IN-VITRO OPIOID WITHDRAWAL", Japanese Journal of Pharmacology, 75(1), 1997, pp. 101-104

Abstract

The effect on the in vitro withdrawal sign induced by naloxone in morphine-dependent guinea pig ileum has been analyzed. Salmon calcitonin (s-CT) dose-dependently reduced the force of the contraction induced by naloxone in morphine incubated tissues, but did not modify the contraction induced by administration of acetylcholine or substance P in non-treated tissues. Therefore, the effect of s-CT in morphine incubatedtissues may not be attributable to postsynaptic mechanisms, and an inhibitory modulation of the excitatory pathways triggered by naloxone would be suggested. In conclusion, s-CT is able to prevent the withdrawal sign in vitro.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 04:37:01