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Titolo:
COMPLETION OF THE DNA-SEQUENCE OF MOUSE ADENOVIRUS TYPE-1 - SEQUENCE OF E2B, L1, AND L2 (18-51 MAP UNITS)
Autore:
MEISSNER JD; HIRSCH GN; LARUE EA; FULCHER RA; SPINDLER KR;
Indirizzi:
UNIV GEORGIA,DEPT GENET ATHENS GA 30602 UNIV GEORGIA,DEPT GENET ATHENS GA 30602
Titolo Testata:
Virus research
fascicolo: 1, volume: 51, anno: 1997,
pagine: 53 - 64
SICI:
0168-1702(1997)51:1<53:COTDOM>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
TERMINAL PROTEIN-PRECURSOR; LINKER-INSERTION MUTAGENESIS; MESSENGER-RNA; 55-KILODALTON PROTEINS; STRUCTURAL PROTEINS; NUCLEOTIDE-SEQUENCE; PRETERMINAL PROTEIN; TRANSCRIPTION UNIT; FUNCTIONAL DOMAINS; OVINE ADENOVIRUS;
Keywords:
MOUSE ADENOVIRUS; MURINE ADENOVIRUS; NUCLEOTIDE SEQUENCE ANALYSIS; DNA POLYMERASE; TERMINAL PROTEIN; 52/55K PROTEIN; PENTON BASE; PROTEIN IIIA; PVII; PROTEIN V; PX; PMU; CORE PROTEINS; LATE PROTEINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
83
Recensione:
Indirizzi per estratti:
Citazione:
J.D. Meissner et al., "COMPLETION OF THE DNA-SEQUENCE OF MOUSE ADENOVIRUS TYPE-1 - SEQUENCE OF E2B, L1, AND L2 (18-51 MAP UNITS)", Virus research, 51(1), 1997, pp. 53-64

Abstract

The DNA sequence of 9991 nt, corresponding to 18-51 map units of mouse adenovirus type 1 (MAV-1), was determined, completing the sequence of the Larsen strain of MAV-1. The length of the complete MAV-1 genome is 30946 nucleotides, consistent with previous experimental estimates. The 18-51 map unit region encodes early region 2B proteins necessary for adenoviral replication as well as late region L1 and L2 structuraland packaging proteins. Sequence comparison in this region with humanadenoviruses indicates broad similarities, including colinear preservation of all recognized open reading frames (ORFs), with highest aminoacid identity occurring in the DNA polymerase and polypeptide III (penton base subunit) ORFs. Virus-associated (VA) RNA is not encoded in the region where VA RNAs are found in the human adenoviruses, between E2B and L1, nor is it encoded anywhere in the entire MAV-1 genome. The MAV-1 polypeptide III lacks the arginine-glycine-aspartic acid (RGD) motif which is involved in an association with cell-surface integrins. Only one RGD sequence is found in an identified coding region in the entire MAV-1 genome, Similar to the porcine adenovirus, this RGD sequence is found in the C-terminus of the MAV-1 fiber protein. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 07:05:29