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Titolo:
CLOZAPINE BLUNTS N-METHYL-D-ASPARTATE ANTAGONIST-INDUCED PSYCHOSIS - A STUDY WITH KETAMINE
Autore:
MALHOTRA AK; ADLER CM; KENNISON SD; ELMAN I; PICKAR D; BREIER A;
Indirizzi:
NIMH,EXPT THERAPEUT BRANCH,NIH,BLDG 10,ROOM 4N212,10 CTR DR BETHESDA MD 20892
Titolo Testata:
Biological psychiatry
fascicolo: 8, volume: 42, anno: 1997,
pagine: 664 - 668
SICI:
0006-3223(1997)42:8<664:CBNAP->2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEGATIVE SYMPTOMS; NMDA-ANTAGONIST; SCHIZOPHRENIA; HALOPERIDOL; PREDICTORS; RECEPTOR; GLYCINE; TRIAL;
Keywords:
KETAMINE; ATYPICAL ANTIPSYCHOTIC; N-METHYL-D-ASPARTATE; CLOZAPINE; PSYCHOSIS; SCHIZOPHRENIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
A.K. Malhotra et al., "CLOZAPINE BLUNTS N-METHYL-D-ASPARTATE ANTAGONIST-INDUCED PSYCHOSIS - A STUDY WITH KETAMINE", Biological psychiatry, 42(8), 1997, pp. 664-668

Abstract

Several lines of evidence suggest that the glutamatergic N-methyl-D-aspartate (NMDA) receptor is involved in the antipsychotic efficacy of the atypical antipsychotic agent clozapine. Clinical data on the interaction between clozapine's mechanism of action and NMDA receptor function have been lacking secondary to a paucity of pharmacologic probes of the NMDA system. We have utilized a double-blind, placebo-controlledinfusion paradigm with subanesthetic doses of the NMDA antagonist ketamine to test the hypothesis that clozapine would blunt ketamine-induced psychotic symptoms in schizophrenic patients. Ten schizophrenic patients underwent ketamine infusions while antipsychotic drug free and also during treatment with clozapine. Antipsychotic drug-free patients experienced increases in ratings of positive and negative symptoms. Clozapine treatment significantly blunted the ketamine-induced increase in positive symptoms. These data suggest that NMDA receptor function may be involved in the unique antipsychotic efficacy of clozapine. Published 1997 by Society of Biological Psychiatry.

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Documento generato il 04/04/20 alle ore 14:25:06