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Titolo:
THE BINDING OF BOTH [H-3] NEMONAPRIDE AND [H-3] RACLOPRIDE IS INCREASED IN SCHIZOPHRENIA
Autore:
MARZELLA PL; HILL C; KEKS N; SINGH R; COPOLOV D;
Indirizzi:
UNIV MELBOURNE,ROYAL VICTORIAN EYE & EAR HOSP,DEPT OTOLARYNGOL,32 GISBORNE ST MELBOURNE 3002 AUSTRALIA MENTAL HLTH RES INST VICTORIA,REBECCA L COOPER RES LABS MELBOURNE VICAUSTRALIA NH & MRC SCHIZOPHRENIA RES UNIT PARKVILLE VIC AUSTRALIA
Titolo Testata:
Biological psychiatry
fascicolo: 8, volume: 42, anno: 1997,
pagine: 648 - 654
SICI:
0006-3223(1997)42:8<648:TBOB[N>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE D-4 RECEPTORS; POSITRON EMISSION TOMOGRAPHY; H-3 RACLOPRIDE BINDING; D4 RECEPTORS; POSTMORTEM BRAINS; STRIATUM; D2; NEMONAPRIDE; ELEVATION; PARKINSONS;
Keywords:
SCHIZOPHRENIA; DOPAMINE D4-LIKE SITES; POSTMORTEM; BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
P.L. Marzella et al., "THE BINDING OF BOTH [H-3] NEMONAPRIDE AND [H-3] RACLOPRIDE IS INCREASED IN SCHIZOPHRENIA", Biological psychiatry, 42(8), 1997, pp. 648-654

Abstract

We performed a postmortem autoradiographic study to compare the density of dopamine D4-like sites in caudate putamen section from age-matched schizophrenia (n = 15) and control (n = 15) populations. The densities of the D4-like sites were estimated by subtracting the density of [H-3]raclopride (binding D2 and D3 receptors) from the density of [H-3]nemonapride (binding D2, D3, and D4 receptors). The findings revealedthat in the schizophrenia population there was a significant increasein the binding of both [H-3]nemonapride (2.3-fold) and [H-3]raclopride (1.9-fold). In addition, in the schizophrenia population the densityof D4-like sites was increased 2.6-fold. (C) 1997 Society of Biological Psychiatry.

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Documento generato il 18/01/20 alle ore 11:50:06