Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
IMMUNOGLOBULIN LEVELS IN PATIENTS WITH CARBOHYDRATE-DEFICIENT GLYCOPROTEIN SYNDROME TYPE-I
Autore:
BJORKLUND JEM; STIBLER H; KRISTIANSSON B; JOHANSSON SGO; MAGNUSSON CGM;
Indirizzi:
KAROLINSKA HOSP,DEPT LAB MED,DIV CLIN IMMUNOL,L204 S-10401 STOCKHOLM SWEDEN KAROLINSKA HOSP,DEPT LAB MED,DIV CLIN IMMUNOL,L204 S-10401 STOCKHOLM SWEDEN KAROLINSKA INST,DEPT LAB MED,DIV CLIN IMMUNOL STOCKHOLM SWEDEN KAROLINSKA HOSP,DEPT NEUROL S-10401 STOCKHOLM SWEDEN EAST HOSP,DEPT PEDIAT GOTHENBURG SWEDEN
Titolo Testata:
International archives of allergy and immunology
fascicolo: 2, volume: 114, anno: 1997,
pagine: 116 - 119
SICI:
1018-2438(1997)114:2<116:ILIPWC>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOCLONAL-ANTIBODIES; IGE; SPECIFICITY;
Keywords:
ALLOTYPE; CARBOHYDRATES; CARBOHYDRATE-DEFICIENT GLYCOPROTEIN SYNDROME; GLYCOPROTEIN; IMMUNOGLOBULIN; INFECTION; SERUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
J.E.M. Bjorklund et al., "IMMUNOGLOBULIN LEVELS IN PATIENTS WITH CARBOHYDRATE-DEFICIENT GLYCOPROTEIN SYNDROME TYPE-I", International archives of allergy and immunology, 114(2), 1997, pp. 116-119

Abstract

Background: The characteristic feature of carbohydrate-deficient glycoprotein syndrome (CDGS) type I, a multisystemic disease, is underglycosylation of many serum glycoproteins, such as transferrin. A few cases of severe infections during childhood have been reported and an underlying immunodeficiency has been suggested. Because of this and the fact that all immunoglobulin (Ig) isotypes are glycoproteins we analysedthe Ig levels in patients with CDGS I. Methods: The serum concentrations of IgG1, IgG2, IgG3, IgG4, IgA, IgM, IgD and IgE, and the frequency of the G2m(23) allotype were measured by enzyme immunoassay in 15 patients with CDGS type I, Results: Ten (67%) patients had an elevated level of at least one Ig, when compared to age-related reference ranges. No particular isotype was involved although a tendency towards high IgE levels was registered. The frequency of homozygous G2m(23)-negative CDGS patients (33%) was not different from that of blood donors (34%). Conclusion: We conclude that CDGS I patients have no major changes in the serum levels of any specific Ig isotype. The severe infections observed in some CDGS patients are therefore unlikely to involve any Ig deficiency, Our results do not exclude that Tg of patients with CDGSmay have altered physiological functions because of abnormal glycosylation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 10:10:29