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Titolo:
ANALGESIA AFTER UPPER ABDOMINAL-SURGERY USING EXTRADURAL ADMINISTRATION OF A FIXED-DOSE OF BUPRENORPHINE IN COMBINATION WITH LIGNOCAINE GIVEN AT 2 INFUSION RATES - A COMPARATIVE-STUDY
Autore:
WAJIMA Z; SHITARA T; ISHIKAWA G; KANEKO K; INOUE T; OGAWA R;
Indirizzi:
NIPPON MED COLL,DEPT ANAESTHESIOL,BUNKYO KU,1-1-5 SENDAGI TOKYO 113 JAPAN CHIBA HOKUSOH HOSP,NIPPON MED SCH,DEPT ANAESTHESIA CHIBA JAPAN
Titolo Testata:
Acta anaesthesiologica Scandinavica
fascicolo: 8, volume: 41, anno: 1997,
pagine: 1061 - 1065
SICI:
0001-5172(1997)41:8<1061:AAUAUE>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDURAL BUPRENORPHINE; POSTOPERATIVE PAIN; MORPHINE; BUPIVACAINE; RELIEF;
Keywords:
BUPRENORPHINE; EXTRADURAL BLOCK; LIGNOCAINE; POSTOPERATIVE PAIN; UPPER ABDOMINAL SURGERY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
Z. Wajima et al., "ANALGESIA AFTER UPPER ABDOMINAL-SURGERY USING EXTRADURAL ADMINISTRATION OF A FIXED-DOSE OF BUPRENORPHINE IN COMBINATION WITH LIGNOCAINE GIVEN AT 2 INFUSION RATES - A COMPARATIVE-STUDY", Acta anaesthesiologica Scandinavica, 41(8), 1997, pp. 1061-1065

Abstract

Background: Extradural administration of combinations of local anaesthetics and opioids are frequently employed for postoperative pain relief. There is a scarcity of data on the analgesic effects of variationsof the dose of local anaesthetic drug admired to a fixed dose of opioid. Methods: Twenty-four patients were investigated after elective upper abdominal surgery. During closure of the abdomen, 2% mepivacaine (8mi) with buprenorphine 0.1 mg (0.5 mi) was given extradurally. After extubation, patients were randomly allocated to receive continuous extradural infusion of a fixed dose of buprenorphine (0.017 mg/h) in combination with 2% lignocaine at either 2.1 ml/h (low rate group, n = 14)or 6.3 ml/h (high rate group, n = 10). Postoperative pain at rest wasassessed using visual analogue scale (VAS) scores and pain at movement by Prince Henry Pain Scale (PHPS) scores. Venous plasma lignocaine concentrations were measured. Results: VAS scores at rest were similar in the two groups at 3 h postoperatively, whereas at 6-24 h postoperatively, VAS scores were higher in the low rate group than in the high rate group. PHPS scores were similar in the two groups at 3 h and at 18h postoperatively, whereas at 6, 9, 12 and 24 h postoperatively, PHPSscores were higher in the low rate group than in the high rate group. Plasma lignocaine concentrations were higher at 23 h postoperatively in the high rate group than at 16 h in both groups, and at 23 h in thelow rate group. At 3 h postoperatively, both the systolic and diastolic arterial pressures were higher in the low rate group than control values obtained on admission. Side effects were observed in one patientin the low rate group who complained of dizziness, and in one patientin the high rate group who complained of nausea. Conclusions: When added to a fixed dose of buprenorphine, continuous extradural infusion of 2% lignocaine at high rate provides better postoperative analgesia than when given at low rate without producing significant side effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 21:19:24