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Titolo:
PLASMA SUPEROXIDE-DISMUTASE AND GLUTATHIONE-PEROXIDASE ACTIVITY IN SPORADIC AMYOTROPHIC-LATERAL-SCLEROSIS
Autore:
MOUMEN R; NOUVELOT A; DUVAL D; LECHEVALIER B; VIADER F;
Indirizzi:
CHU COTE NACRE,NEUROL SERV,VASTEL F-14033 CAEN FRANCE CHU COTE NACRE,NEUROL SERV,VASTEL F-14033 CAEN FRANCE UNIV CAEN,EQUIPE HYDROLASES & CYTOTOX F-14032 CAEN FRANCE UNIV CAEN,CNRS UMR 6551 F-14032 CAEN FRANCE
Titolo Testata:
Journal of the neurological sciences
fascicolo: 1, volume: 151, anno: 1997,
pagine: 35 - 39
SICI:
0022-510X(1997)151:1<35:PSAGAI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOTOR-NEURON DISEASE; CU/ZN-SUPEROXIDE; CEREBROSPINAL-FLUID; MOTONEURON DISEASE; ANTERIOR HORN; FREE-RADICALS; SPINAL-CORD; BRAIN; MUTATIONS; SELENIUM;
Keywords:
AMYOTROPHIC LATERAL SCLEROSIS; GLUTATHIONE PEROXIDASE; MALONE DIALDEHYDE; SUPEROXIDE DISMUTASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
R. Moumen et al., "PLASMA SUPEROXIDE-DISMUTASE AND GLUTATHIONE-PEROXIDASE ACTIVITY IN SPORADIC AMYOTROPHIC-LATERAL-SCLEROSIS", Journal of the neurological sciences, 151(1), 1997, pp. 35-39

Abstract

To determine the possible role of oxydative stress in the pathology of amyotrophic lateral sclerosis (SALS), we measured the plasma activities of superoxide dismutase (SOD) and glutathione peroxidase (GPX), together with GPX and malone dialdehyde (MDA, a marker of lipoperoxydation) plasma concentrations in a sample of 21 SALS patients and 7 normalcontrol (NC) subjects. MDA concentration and SOD activity were significantly higher, whereas GPX activity was significantly lower in SALS patients than in NC. Increased MDA concentration provides indirect confirmation of excess lipoperoxydation. Increased plasma SOD activity might I reflect the involvement of extra-cellular SOD (SOD3), a hitherto unreported finding in SALS. Impaired GPX activity, which has already been found in red blood cells and brain tissue of SALS patients, might play a part in the pathogenesis of this disease. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:07:18