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Titolo:
EVALUATION OF THE SAFETY AND EFFICACY OF KETOROLAC VERSUS MORPHINE BYPATIENT-CONTROLLED ANALGESIA FOR POSTOPERATIVE PAIN
Autore:
OHARA DA; FANCIULLO G; HUBBARD L; MANEATIS T; SEUFFERT P; BYNUM L; SHEFRIN A;
Indirizzi:
BECTON DICKINSON CORP,13-01 POLLITT DR FAIR LAWN NJ 07410 UNIV MED & DENT NEW JERSEY,ROBERT WOOD JOHNSON MED SCH,DEPT ANESTHESIA NEW BRUNSWICK NJ 00000 BRIGHAM & WOMENS HOSP,DEPT ANESTHESIA BOSTON MA 02115 SCHUMPERT HOSP,DEPT ANESTHESIA SHREVEPORT LA 00000 HOFFMANN LA ROCHE,DEPT ANESTHESIA NUTLEY NJ 00000
Titolo Testata:
Pharmacotherapy
fascicolo: 5, volume: 17, anno: 1997,
pagine: 891 - 899
SICI:
0277-0008(1997)17:5<891:EOTSAE>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAMUSCULAR KETOROLAC; TROMETHAMINE; MEPERIDINE; CHOLECYSTECTOMY; SURGERY; TIME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
D.A. Ohara et al., "EVALUATION OF THE SAFETY AND EFFICACY OF KETOROLAC VERSUS MORPHINE BYPATIENT-CONTROLLED ANALGESIA FOR POSTOPERATIVE PAIN", Pharmacotherapy, 17(5), 1997, pp. 891-899

Abstract

Study Objective. To compare ketorolac tromethamine with morphine for pain management after major abdominal surgery. Design. Double-blind, randomized study. Setting. Hospital recovery room and postoperative surgical unit. Patients. One hundred ninety-one patients with at least moderate pain after major abdominal surgery. Interventions. Patients received ketorolac by patient-controlled analgesia (PCA) bolus alone (KetB), ketorolac by bolus plus infusion (Ket I), or morphine by PCA bolus (morphine), with injectable morphine available for supplementation. Measurements and Main Results. Levels of sedation, pain intensity, pain relief, and adverse events were recorded at baseline, at 2, 4, and 6hours, and at termination. Supplemental morphine was required by 71% of Ket B patients, 67% of Ket I patients, and 38% of morphine patients(p less than or equal to 0.001 for Ket B vs morphine). Although patients receiving ketorolac required more supplemental morphine than the morphine group (6.0 mg Ket I, 6.2 mg Ket B, 4.0 mg morphine), there wasa large morphine-sparing effect in both ketorolac groups (total morphine 6.0 mg Ket I, 6.2 mg Ket B, 33.3 mg morphine). Overall pain reliefscores were similar for morphine and Ket I groups, and were lower forKet B than for morphine (p=0.002). There were no differences among groups in numbers of patients with adverse events. Conclusion. Ketorolacmay be effective when administered by PCA device, and has a clear morphine-sparing effect.

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Documento generato il 13/07/20 alle ore 10:59:41