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Titolo:
SELECTED METHODOLOGICAL ISSUES IN MEIOTIC MAPPING OF OBESITY GENES INHUMANS - ISSUES OF POWER AND EFFICIENCY
Autore:
ALLISON DB; SCHORK NJ;
Indirizzi:
COLUMBIA UNIV,COLL PHYS & SURG,ST LUKES ROOSEVELT HOSP,OBES RES CTR,1090 AMSTERDAM AVE NEW YORK NY 10025 CASE WESTERN RESERVE UNIV,DEPT GENET CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,DEPT BIOSTAT & EPIDEMIOL CLEVELAND OH 44106 HARVARD UNIV,SCH PUBL HLTH,DEPT BIOSTAT BOSTON MA 02115 JACKSON LAB BAR HARBOR ME 04609 MILLENNIUM PHARMACEUT CAMBRIDGE MA 00000
Titolo Testata:
Behavior genetics
fascicolo: 4, volume: 27, anno: 1997,
pagine: 401 - 421
SICI:
0001-8244(1997)27:4<401:SMIIMM>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUANTITATIVE-TRAIT LOCI; MULTIPOINT LINKAGE ANALYSIS; GENETICALLY COMPLEX TRAITS; DISCORDANT SIB PAIRS; HUMAN OB GENE; RELATIVE-PAIRS; PIMA-INDIANS; BETA(3)-ADRENERGIC RECEPTOR; SAMPLING CONSIDERATIONS; FOUNDER POPULATIONS;
Keywords:
MEIOTIC MAPPING; OBESITY GENES; POWER; EFFICIENCY; METHODOLOGICAL ISSUES; LINKAGE; DISEQUILIBRIUM MAPPING; EXTREME SAMPLING;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
137
Recensione:
Indirizzi per estratti:
Citazione:
D.B. Allison e N.J. Schork, "SELECTED METHODOLOGICAL ISSUES IN MEIOTIC MAPPING OF OBESITY GENES INHUMANS - ISSUES OF POWER AND EFFICIENCY", Behavior genetics, 27(4), 1997, pp. 401-421

Abstract

This paper focuses on methods for mapping novel obesity genes in humans via meiotic mapping techniques. By novel we mean genes that are as yet unidentified as playing a role in obesity. We begin by presenting a discussion of why we believe it is important to seek out novel obesity genes and, in particular, novel genes of small effect. In light of the arguably Herculean task of finding genes of small effect with conventional gene mapping methods, we discuss alternative methods and procedures that may enhance our ability to map never obesity genes of small effect. Many of these methods have been discussed previously in the literature and are summarized here. These include reconceptualizing power in the context of genomewide scans, multivariate linkage approaches, the use of phenotypically extreme subjects, and the use of large sibships. These are discussed in the context of linkage studies. Association studies and disequilibrium mapping are also discussed, and again,issues involving the use of extreme phenotypes and multiple testing are included. We also provide a brief discussion of DNA pooling and transmission disequilibrium tests for quantitative traits. Finally, we advocate data pooling techniques (e.g., meta-analysis) to enhance the power and efficiency of the entire field of the genetics of obesity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 17:03:45