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Titolo:
ALPHA-V-BETA-3 INTEGRIN ASSOCIATES WITH ACTIVATED INSULIN AND PDGF-BETA RECEPTORS AND POTENTIATES THE BIOLOGICAL-ACTIVITY OF PDGF
Autore:
SCHNELLER M; VUORI K; RUOSLAHTI E;
Indirizzi:
LA JOLLA CANC RES FDN,CANC RES CTR,BURNHAM INST,10901 N TORREY PINES RD LA JOLLA CA 92037 LA JOLLA CANC RES FDN,CANC RES CTR,BURNHAM INST LA JOLLA CA 92037
Titolo Testata:
EMBO journal
fascicolo: 18, volume: 16, anno: 1997,
pagine: 5600 - 5607
SICI:
0261-4189(1997)16:18<5600:AIAWAI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOCAL ADHESION KINASE; GROWTH-FACTOR; SIGNAL-TRANSDUCTION; TYROSINE PHOSPHORYLATION; CELL-MIGRATION; MELANOMA-CELLS; IN-VITRO; PROTEIN; VITRONECTIN; EXPRESSION;
Keywords:
ALPHA-V-BETA-3 INTEGRIN; CELL ATTACHMENT; CELL-MATRIX INTERACTION; GROWTH FACTORS; PDGF-BETA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
M. Schneller et al., "ALPHA-V-BETA-3 INTEGRIN ASSOCIATES WITH ACTIVATED INSULIN AND PDGF-BETA RECEPTORS AND POTENTIATES THE BIOLOGICAL-ACTIVITY OF PDGF", EMBO journal, 16(18), 1997, pp. 5600-5607

Abstract

Integrin-mediated cell attachment modulates growth responses and growth factors regulate cell attachment. Moreover, both cell attachment toextracellular matrix and mitogenic signaling by growth factors are necessary for the proliferation of most types of normal cells, suggesting that integrin and growth factor receptor signaling pathways meet at some downstream point, We report here that a small, highly tyrosine-phosphorylated fraction of PDGF beta and insulin receptors co-immunoprecipitates with the alpha v beta 3 integrin from cells, The integrin association requires growth factor stimulation of the receptors, Several signaling molecules that are known to be associated with activated growth factor receptors were present in the alpha v beta 3 integrin complexes. Mitogenicity and chemotaxis induced by PDGF-BB were enhanced in cells plated on the alpha v beta 3 ligand vitronectin compared with cells plated on the beta 1 integrin ligand collagen, Thus, the engagement of the alpha v beta 3 integrin in cell-matrix interactions appears to coordinate an intense response to growth factors, helping to explainthe importance of this integrin for tissue regeneration, angiogenesisand tumor metastasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 00:52:42