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Titolo:
NUCLEOTIDE(-258) G-TO-A TRANSITION VARIANT OF THE LIVER GLUCOKINASE GENE IS ASSOCIATED WITH ESSENTIAL-HYPERTENSION
Autore:
CHIANG FT; CHIU KC; TSENG YZ; LEE KC; CHUANG LM;
Indirizzi:
NATL TAIWAN UNIV HOSP,DEPT INTERNAL MED,7 CHUNG SHAN S RD TAIPEI 10016 TAIWAN NATL TAIWAN UNIV,COLL MED,DEPT INTERNAL MED TAIPEI TAIWAN NATL TAIWAN UNIV,COLL MED,LAB MED TAIPEI TAIWAN UNIV CALIF LOS ANGELES,SCH MED,DEPT MED,DIV ENDOCRINOL & METAB LOS ANGELES CA 90024
Titolo Testata:
American journal of hypertension
fascicolo: 9, volume: 10, anno: 1997,
parte:, 1
pagine: 1049 - 1052
SICI:
0895-7061(1997)10:9<1049:NGTVOT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIABETES-MELLITUS; INSULIN; GLUCOSE; NIDDM; IDENTIFICATION; RESISTANCE; MUTATIONS; PROMOTER;
Keywords:
GLUCOKINASE; HYPERTENSION; INSULIN RESISTANCE; NON-INSULIN-DEPENDENT DIABETES MELLITUS; TAIWANESE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
F.T. Chiang et al., "NUCLEOTIDE(-258) G-TO-A TRANSITION VARIANT OF THE LIVER GLUCOKINASE GENE IS ASSOCIATED WITH ESSENTIAL-HYPERTENSION", American journal of hypertension, 10(9), 1997, pp. 1049-1052

Abstract

Hypertension is a complex disease with strong genetic influences. Essential hypertension has been shown to be associated with insulin resistance. A molecular variant with G-to-A transition at the nucleotide -258 of the liver glucokinase (GCK) promoter was found in diabetic patients. The variant A allele is associated with insulin resistance. We examine the role of this genetic variant in the pathogenesis of hypertension using a population association study. We recruited 205 Taiwanese subjects and they were divided into two groups based on either presence (65 subjects) or absence (140 subjects) of essential hypertension. Genomic DNA was extracted from peripheral leukocytes. Genotypes at thislocus were determined by using a polymerase chain reaction restriction fragment length polymorphism. The distribution of genotypic frequency was different between the hypertensive and control groups (P = .009). The frequency of variant A allele was greater in hypertensive subjects than in control (23% v 10%, P = .001). Subjects with at least an A allele had a risk for hypertension by 2.52 times (95% confidence interval 1.29 to 4.91) as compared with those without an A allele, Thus, wefirst demonstrate the association between the G-to-A variants at the nucleotide -258 of the liver GCK gene and essential hypertension. Thismay explain the insulin resistance in essential hypertension and the variant A allele as a risk factor for essential hypertension in the Taiwanese population. (C) 1997 American Journal of Hypertension, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 02:06:13