Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
INTRASEPTAL FLUMAZENIL ENHANCES, WHILE DIAZEPAM-BINDING INHIBITOR IMPAIRS, PERFORMANCE IN A WORKING-MEMORY TASK
Autore:
HERZOG CD; STACKMAN RW; WALSH TJ;
Indirizzi:
RUTGERS STATE UNIV,DEPT PSYCHOL NEW BRUNSWICK NJ 08903 RUTGERS STATE UNIV,DEPT PSYCHOL NEW BRUNSWICK NJ 08903
Titolo Testata:
Neurobiology of learning and memory
fascicolo: 3, volume: 66, anno: 1996,
pagine: 341 - 352
SICI:
1074-7427(1996)66:3<341:IFEWDI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
BENZODIAZEPINE RECEPTOR ANTAGONIST; ELEVATED PLUS-MAZE; RAT-BRAIN; ACETYLCHOLINE-RELEASE; ANXIOGENIC ACTION; INVERSE-AGONIST; BETA-CARBOLINES; MUSCIMOL; AMYGDALA; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
C.D. Herzog et al., "INTRASEPTAL FLUMAZENIL ENHANCES, WHILE DIAZEPAM-BINDING INHIBITOR IMPAIRS, PERFORMANCE IN A WORKING-MEMORY TASK", Neurobiology of learning and memory, 66(3), 1996, pp. 341-352

Abstract

GABA(A)/benzodiazepine receptors in the medial septum modulate the activity of cholinergic neurons that innervate the hippocampus. Injection of benzodiazepine (BDZ) agonists into the medial septum impairs working memory performance and decreases high-affinity choline transport (HAChT) in the hippocampus. In contrast, intraseptal injection of the BDZ antagonist flumazenil increases HAChT and prevents the memory deficits induced by systemic BDZs. The present studies attempted to furthercharacterize the behavioral effects of medial septal injections of flumazenil to an endogenous negative modulator of the GABA(A)/BDZ receptor complex, diazepam binding inhibitor (DBI). Male Sprague-Dawley ratswere cannulated to study the effects of intraseptal injections of these BDZ ligands on spatial working memory, anxiety-related behaviors inthe elevated plus maze, and on general locomotor activity. Intraseptal flumazenil (10 nmol/0.5 mu l) produced a delay-dependent enhancementof DNMTS performance after an 8-h, but not a 4-h, delay interval. This promnestic dose of flumazenil had no effect on locomotor activity and did not produce changes in measures of anxiety on the plus maze. Intraseptal injection of DBI had no effect (8 nmol/0.5 mu l) or slightly impaired (4 nmol/0.5 mu l) DNMTS radial maze performance following an 8-h delay, without producing changes in locomotion or plus maze behavior. These data demonstrate that flumazenil has a unique profile of activity in enhancing working memory following intraseptal injection. (C)1996 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:08:26