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Titolo:
THE EFFECTS OF NEW HYPNOTIC DRUGS IN RATS TRAINED TO DISCRIMINATE ETHANOL
Autore:
SANGER DJ;
Indirizzi:
SYNTHELABO RECH,31 AVE P VAILLANT COUTURIER F-92220 BAGNEUX FRANCE
Titolo Testata:
Behavioural pharmacology
fascicolo: 4, volume: 8, anno: 1997,
pagine: 287 - 292
SICI:
0955-8810(1997)8:4<287:TEONHD>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-ASPARTATE ANTAGONISTS; STIMULUS PROPERTIES; PHARMACOKINETIC PROPERTIES; PHARMACOLOGICAL PROFILES; BEHAVIORAL PHARMACOLOGY; ZOLPIDEM; RECEPTOR; BENZODIAZEPINE; ZOPICLONE; CHLORDIAZEPOXIDE;
Keywords:
DRUG DISCRIMINATION; ETHANOL; RAT; SX 3228; ZALEPLON; ZOLPIDEM; ZOPICLONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
D.J. Sanger, "THE EFFECTS OF NEW HYPNOTIC DRUGS IN RATS TRAINED TO DISCRIMINATE ETHANOL", Behavioural pharmacology, 8(4), 1997, pp. 287-292

Abstract

Several new, non-benzodiazepine hypnotic drugs have recently been marketed (zopiclone, zolpidem) or are in development (zaleplon, SX 3228). These compounds act at benzodiazepine (BZ) (omega) receptors but havemechanisms of action which are not identical to those of benzodiazepines; in particular, zolpidem, zaleplon and SX 3228 have been reported to have selectivity for the BZ(1) (omega(1)) receptor subtype. In the present study the effects of the four hypnotic drugs were investigatedin rats trained to discriminate ethanol (1 g/kg). Comparisons were made with pentobarbital and the benzodiazepines, lorazepam and midazolam. The two benzodiazepines and the barbiturate produced dose-related substitution for ethanol. In contrast, zolpidem, zaleplon, SX 3228 and zopiclone gave rise to only partial (maximum effect 50-67%) substitution, even at doses which greatly reduced rates of lever pressing. The limited ethanol-like effects of zolpidem, zaleplon and SX 3228 may be related to the more selective mechanism of action of these compounds. Itis not clear why the effects of zopiclone differed from those of the benzodiazepines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:15:29