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Titolo:
TREATMENT OF FUNCTIONAL DECLINE IN ADULTS WITH DOWN-SYNDROME USING SELECTIVE SEROTONIN-REUPTAKE INHIBITOR DRUGS
Autore:
GELDMACHER DS; LERNER AJ; VOCI JM; NOELKER EA; SOMPLE LC; WHITEHOUSE PJ;
Indirizzi:
CLEVELAND STATE UNIV,ALZHEIMER CTR,12200 FAIRHILL RD CLEVELAND OH 44120 UNIV HOSP CLEVELAND,ALZHEIMER CTR CLEVELAND OH 44106 UNIV HOSP CLEVELAND,JOSEPH M FOLEY ELDER HLTH CTR CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,SCH MED,DEPT NEUROL CLEVELAND OH 44106
Titolo Testata:
Journal of geriatric psychiatry and neurology
fascicolo: 3, volume: 10, anno: 1997,
pagine: 99 - 104
SICI:
0891-9887(1997)10:3<99:TOFDIA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOWNS-SYNDROME; NEUROTRANSMITTER DEFICITS; MAJOR DEPRESSION; DEMENTIA; BRAIN; 5-HYDROXYTRYPTAMINE; INDIVIDUALS; DISEASE; PEOPLE; AGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
D.S. Geldmacher et al., "TREATMENT OF FUNCTIONAL DECLINE IN ADULTS WITH DOWN-SYNDROME USING SELECTIVE SEROTONIN-REUPTAKE INHIBITOR DRUGS", Journal of geriatric psychiatry and neurology, 10(3), 1997, pp. 99-104

Abstract

Alzheimer's disease (AD) is a common cause of functional decline in Down syndrome (DS) adults. Acquired cognitive deficits may be difficultto evaluate in the context of baseline impairments. Behavioral symptoms are also common and may represent the effects of depression, AD, orboth. Therefore, the objective of this study was to report a clinicalcase series of selected adults with DS and behavioral change who responded to treatment with selective serotonin-reuptake inhibitor (SSRI) medication, Six patients, aged 23 to 63 years, 5 women and 1 man, withthe clinical diagnosis of DS presented for diagnosis and treatment offunctional decline in adult life, Noncognitive symptoms were prominent and included aggression, social withdrawal, and compulsive behaviors, Memory dysfunction was reported in varying degrees. Treatment with SSRI antidepressants was instituted for depressive, apathetic, and compulsive behaviors. Treated patients showed improvement in behaviors as reported by caregivers, and on objective measures, such as workplace productivity, Noncognitive symptoms are a cardinal feature of functional decline in adults with DS and may represent either depression or AD,In some patients, the symptoms respond well to SSRI agents with concomitant improvement in daily function, Treatment trials with SSRIs may,therefore, be warranted in such cases.

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Documento generato il 21/10/20 alle ore 15:39:45