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Titolo:
CHANGES IN MUCOSAL FATTY-ACID PROFILE IN INFLAMMATORY BOWEL-DISEASE AND IN EXPERIMENTAL COLITIS - A COMMON RESPONSE TO BOWEL INFLAMMATION
Autore:
FERNANDEZBANARES F; ESTEVECOMAS M; MANE J; NAVARRO E; BERTRAN X; CABRE E; BARTOLI R; BOIX J; PASTOR C; GASSULL MA;
Indirizzi:
HOSP UNIV GERMANS TRIAS & PUJOL,RES UNIT,DEPT GASTROENTEROL,CARRETERADEL CANYET S-N BADALONA 08916 SPAIN HOSP UNIV GERMANS TRIAS & PUJOL,RES UNIT,DEPT GASTROENTEROL BADALONA 08916 SPAIN
Titolo Testata:
Clinical nutrition
fascicolo: 4, volume: 16, anno: 1997,
pagine: 177 - 183
SICI:
0261-5614(1997)16:4<177:CIMFPI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVE CROHNS-DISEASE; DOCOSAHEXAENOIC ACID; COLONIC MUCOSA; FISH-OIL; PHOSPHOLIPIDS; CELLS; MODEL; DIETS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
F. Fernandezbanares et al., "CHANGES IN MUCOSAL FATTY-ACID PROFILE IN INFLAMMATORY BOWEL-DISEASE AND IN EXPERIMENTAL COLITIS - A COMMON RESPONSE TO BOWEL INFLAMMATION", Clinical nutrition, 16(4), 1997, pp. 177-183

Abstract

Background and aims: Plasma polyunsaturated fatty acid profile in patients with inflammatory bowel disease is abnormal. We aimed to assess the mucosal fatty acid pattern in patients with ulcerative colitis andCrohn's disease, and in rats with trinitrobenzene-sulfonic acid (TNB)induced colitis. Methods: Fatty acids were measured in colonic mucosaof patients with ulcerative colitis (n = 30), Crohn's disease (n = 21), and healthy controls (n = 13). Likewise, they were assessed in the colonic mucosa of rats with TNB- and sham-colitis. Results: There was an increase of the end-products (C22:5n3, C22:6n3, C20:4n6, C22:5n6) and a decrease of the precursors (C18:3n3, C18:2n6) of both n3 and n6 polyunsaturated fatty acids in the mucosa of active ulcerative colitis and TNB-colitis. Also, high values of saturated (C16:0, C18:0) and lowvalues of monounsaturated fatty acids (C18:1n9) were observed. Furthermore, the mucosa of active Crohn's disease showed substantial changesin saturated, monounsaturated and essential fatty acids, but not in polyunsaturated fatty acids. Mucosa of patients with inactive disease showed intermediate fatty acid values between the mucosa of active patients and healthy controls. Conclusions: Colonic inflammation causes a characteristic modification of the mucosal fatty acid profile which appears to be common to different aetiologies and seems to be related tothe degree of inflammation.

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Documento generato il 29/11/20 alle ore 09:54:07