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Titolo:
CRM1 IS AN EXPORT RECEPTOR FOR LEUCINE-RICH NUCLEAR EXPORT SIGNALS
Autore:
FORNEROD M; OHNO M; YOSHIDA M; MATTAJ IW;
Indirizzi:
EUROPEAN MOL BIOL LAB D-69117 HEIDELBERG GERMANY EUROPEAN MOL BIOL LAB D-69117 HEIDELBERG GERMANY UNIV TOKYO,DEPT BIOTECHNOL TOKYO 113 JAPAN
Titolo Testata:
Cell
fascicolo: 6, volume: 90, anno: 1997,
pagine: 1051 - 1060
SICI:
0092-8674(1997)90:6<1051:CIAERF>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING PROTEIN COMPLEX; ORDER CHROMOSOME STRUCTURE; REV ACTIVATION DOMAIN; U-SNRNA EXPORT; NUCLEOCYTOPLASMIC TRANSPORT; HNRNP A1; REGULATORY PROTEINS; LEPTOMYCIN-B; TRANSFER-RNA; HIV REV;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
63
Recensione:
Indirizzi per estratti:
Citazione:
M. Fornerod et al., "CRM1 IS AN EXPORT RECEPTOR FOR LEUCINE-RICH NUCLEAR EXPORT SIGNALS", Cell, 90(6), 1997, pp. 1051-1060

Abstract

CRM1 is distantly related to receptors that mediate nuclear protein import and was previously shown to interact with the nuclear pore complex. Overexpression of CRM1 in Xenopus oocytes stimulates Rev and U snRNA export from the nucleus. Conversely, leptomycin B, a cytotoxin thatis shown to bind to CRM1 protein, specifically inhibits the nuclear export of Rev and U snRNAs. In vitro, CRM1 forms a leptomycin B-sensitive complex involving cooperative binding of both RanGTP and the nuclear export signal (NES) from either the Rev or PKI proteins. We concludethat CRM1 is an export receptor for leucine-rich nuclear export signals and discuss a model for the role of RanGTP in CRM1 function and in nuclear export in general.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 12:13:22