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Titolo:
AIRWAY EPITHELIUM AS AN EFFECTOR OF INFLAMMATION - MOLECULAR REGULATION OF SECONDARY MEDIATORS
Autore:
MARTIN LD; ROCHELLE LG; FISCHER BM; KRUNKOSKY TM; ADLER KB;
Indirizzi:
N CAROLINA STATE UNIV,COLL VET MED,DEPT ANAT PHYSIOL SCI & RADIOL,4700 HILLSBOROUGH ST RALEIGH NC 27606 N CAROLINA STATE UNIV,COLL VET MED,DEPT ANAT PHYSIOL SCI & RADIOL RALEIGH NC 27606
Titolo Testata:
The European respiratory journal
fascicolo: 9, volume: 10, anno: 1997,
pagine: 2139 - 2146
SICI:
0903-1936(1997)10:9<2139:AEAAEO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; TUMOR-NECROSIS-FACTOR; PLATELET-ACTIVATING-FACTOR; COLONY-STIMULATING FACTOR; INTERLEUKIN-8 GENE-EXPRESSION; ARACHIDONIC-ACID METABOLISM; RESPIRATORY SYNCYTIAL VIRUS; CELLS IN-VITRO; MESSENGER-RNA; INTERFERON-GAMMA;
Keywords:
AIRWAY; CYTOKINES; EICOSANOIDS; EPITHELIUM; INFLAMMATION; REACTIVE OXYGEN/NITROGEN SPECIES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
101
Recensione:
Indirizzi per estratti:
Citazione:
L.D. Martin et al., "AIRWAY EPITHELIUM AS AN EFFECTOR OF INFLAMMATION - MOLECULAR REGULATION OF SECONDARY MEDIATORS", The European respiratory journal, 10(9), 1997, pp. 2139-2146

Abstract

Deleterious environmental stimuli cause the airway epithelium to respond with increased secretions of mucus, reaction of oxygen/nitrogen species, changes in ciliary beating, and the influx of inflammatory cells, The epithelium is a target for factors released by infiltrating inflammatory cells, and has recently been shown to serve as an effector of such inflammation, Molecular mechanisms regulating production of secondary inflammatory mediators (cytokines, lipid mediators, and reactive oxygen/nitrogen species) have yet to be fully described. This reportreviews the production of secondary mediators by epithelial cells andby airway epithelium. Lipid mediators are enzymatically produced by the airway epithelium in response to primary mediators, Molecular mechanisms regulating the production of cyclo-oxygenase, lipoxygenase and prostaglandin synthase are discussed, along with the potential of lipidmediators to produce inflammation, The molecular regulation of nitricoxide production is also described in the context of its role as a signalling molecule in pathways regulating secretion of mucus, ciliary motion, and intercellular adhesion molecule-1 (ICAM-1) expression, The production of cytokines by the airway epithelium is shown to play a role in causing inflammation associated with respiratory diseases, Particular attention is paid to molecular mechanisms governing the expression of tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-8 (IL-8).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 21:11:12