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Titolo:
PREVIOUS TREATMENT AS A CONFOUNDING VARIABLE IN STUDIES WITH NOVEL ANTIPSYCHOTICS - 2 CASES OF HIGH DOPAMINE-2 RECEPTOR OCCUPANCY WITH QUETIAPINE
Autore:
TAUSCHER J; KUFFERLE B; ASENBAUM S; BRUCKE T; KASPER S;
Indirizzi:
UNIV VIENNA,DEPT GEN PSYCHIAT,WAHRINGER GURTEL 18-20 A-1090 VIENNA AUSTRIA UNIV VIENNA,DEPT CLIN NEUROL A-1090 VIENNA AUSTRIA
Titolo Testata:
Psychopharmacology
fascicolo: 1, volume: 133, anno: 1997,
pagine: 102 - 105
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; SCHIZOPHRENIC-PATIENTS; NEUROLEPTICS; DRUGS;
Keywords:
IBZM SPECT; DOPAMINE-2 RECEPTORS; QUETIAPINE; HALOPERIDOL; CLOPENTHIXOL DECANOATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
J. Tauscher et al., "PREVIOUS TREATMENT AS A CONFOUNDING VARIABLE IN STUDIES WITH NOVEL ANTIPSYCHOTICS - 2 CASES OF HIGH DOPAMINE-2 RECEPTOR OCCUPANCY WITH QUETIAPINE", Psychopharmacology, 133(1), 1997, pp. 102-105

Abstract

Previous treatment call be a confounding variable in studies with novel antipsychotics, Quetiapine is a new antipsychotic substance with a low affinity for dopamine-2 (D-2) receptors. Preliminary SPECT and PETinvestigations revealed only a low striatal D-2 receptor occupancy rate, However, we present two cases of high striatal D2 receptor occupancy (51% and 71%) measured with I-123 IBZM SPECT during quetiapine monotherapy. Both patients had previously received continuous treatment with typical neuroleptics. Mie present evidence that the previous antipsychotic therapy influenced D-2 receptor binding of I-123 IBZM during quetiapine treatment weeks after cessation of typical neuroleptics. This might be of importance for the design of clinical trials and brain imaging studies in the future.

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Documento generato il 17/09/19 alle ore 22:37:49