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Titolo:
RELATIONSHIP BETWEEN THE CYP2D6 GENOTYPE AND THE STEADY-STATE PLASMA-CONCENTRATIONS OF TRAZODONE AND ITS ACTIVE METABOLITE M-CHLOROPHENYLPIPERAZINE
Autore:
MIHARA K; OTANI K; SUZUKI A; YASUI N; NAKANO H; MENG XM; OHKUBO T; NAGASAKI T; KANEKO S; TSUCHIDA S; SUGAWARA K; GONZALEZ FJ;
Indirizzi:
HIROSAKI UNIV HOSP,DEPT NEUROPSYCHIAT HIROSAKI AOMORI 036 JAPAN HIROSAKI UNIV HOSP,DEPT NEUROPSYCHIAT HIROSAKI AOMORI 036 JAPAN HIROSAKI UNIV HOSP,DEPT BIOCHEM 2 HIROSAKI AOMORI 036 JAPAN HIROSAKI UNIV HOSP,DEPT PHARM HIROSAKI AOMORI 036 JAPAN GOSHOGAWARA CITY HOSP,DEPT PHARM GOSHOGAWARA 037 JAPAN NCI,MOL CARCINOGENESIS LAB,NIH BETHESDA MD 20014
Titolo Testata:
Psychopharmacology
fascicolo: 1, volume: 133, anno: 1997,
pagine: 95 - 98
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEBRISOQUINE HYDROXYLATION; DEPRESSED-PATIENTS; POOR METABOLIZERS; GENETIC-ANALYSIS; SPARTEINE; PHENOTYPE; DELETION; ALLELE; LOCUS; IDENTIFICATION;
Keywords:
CYP2D6 GENOTYPE; TRAZODONE; M-CHLOROPHENYLPIPERAZINE; STEADY-STATE PLASMA CONCENTRATION; METABOLISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
K. Mihara et al., "RELATIONSHIP BETWEEN THE CYP2D6 GENOTYPE AND THE STEADY-STATE PLASMA-CONCENTRATIONS OF TRAZODONE AND ITS ACTIVE METABOLITE M-CHLOROPHENYLPIPERAZINE", Psychopharmacology, 133(1), 1997, pp. 95-98

Abstract

The relationship between the cytochrome P450 (CYP) 2D6 genotype and the steady-state plasma concentrations (Css) of trazodone and its active metabolite m-chlorophenylpiperazine (mCPP) was studied in 54 depressed Japanese patients receiving trazodone 150 mg at bedtime. By use of allele-specific PCR analysis, the wild type allele, three mutated alleles causing absent enzyme activity (CYP2D6A, CYP2D6B and CYP2D6D) and one mutated allele causing decreased enzyme activity (CYPZD6 Ch) were identified. The means (ranges) of the Css of trazodone, corrected to the median body weight in 17 cases with no mutated allele, 27 cases with one mutated allele and 10 cases with two mutated alleles, were 556 (281-1115), 643 (302-1362) and 671 (234-1418) ng/ml, respectively, while the values of mCPP were 60 (35-121), 65 (33-99) and 58 (38-112) ng/ml, respectively. Neither the Css of trazodone (F = 0.80, P = 0.45) northat of mCPP (F = 0.49, P = 0.61) significantly differed among the three groups. The present study thus suggests that the CYP2D6 genotype cannot predict the Css of these compounds.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:42:57