Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
AMPLIFICATION OF T-CELL AND ANTIBODY-RESPONSES IN DNA-BASED IMMUNIZATION WITH HIV-1 NEF BY COINJECTION WITH A GM-CSF EXPRESSION VECTOR
Autore:
SVANHOLM C; LOWENADLER B; WIGZELL H;
Indirizzi:
PHARMACIA & UPJOHN INC,STRANDBERGSGATAN 47 S-11287 STOCKHOLM SWEDEN KAROLINSKA INST,MICROBIOL & TUMORBIOL CTR STOCKHOLM SWEDEN ASTRA HASSLE AB,DEPT MOL BIOL MOLNDAL SWEDEN
Titolo Testata:
Scandinavian journal of immunology
fascicolo: 3, volume: 46, anno: 1997,
pagine: 298 - 303
SICI:
0300-9475(1997)46:3<298:AOTAAI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; COLONY-STIMULATING FACTOR; PLASMID DNA; PROTECTIVE IMMUNITY; VIRAL PROTEIN; ANTIGEN; VACCINATION; LYMPHOMA; TUBERCULOSIS; ENHANCEMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
C. Svanholm et al., "AMPLIFICATION OF T-CELL AND ANTIBODY-RESPONSES IN DNA-BASED IMMUNIZATION WITH HIV-1 NEF BY COINJECTION WITH A GM-CSF EXPRESSION VECTOR", Scandinavian journal of immunology, 46(3), 1997, pp. 298-303

Abstract

Intradermal inoculation of mice with naked plasmid DNA encoding the regulatory HIV-1 Nef protein was shown to induce Nef-specific T and B cell responses. Co-inoculation with an expression vector encoding murine granulocyte-macrophage colony-stimulating factor (GM-CSF), a cytokine known to facilitate the induction of primary immune responses, resulted in a markedly enhanced response to Nef. This was manifested both as an increase in Nef-specific T cell responses and antibody levels. DNA immunization with the Nef and GM-CSF vectors induced primarily a Th1response as judged by the raised levels of both IFN-gamma and IL-2, from re-stimulated T cells. The immunostimulatory activity of GM-CSF DNA was locally restricted and was observed only if both plasmid vectorswere injected at the same site.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 05:11:29