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Titolo:
BLOOD-FLOW DIAGNOSTICS OF BREAST-TUMORS UNDER INCREASED BLOOD-PRESSURE - NEW POSSIBILITIES IN ESTABLISHING THE NATURE OF THE TUMOR
Autore:
SOHN C; BELDERMANN F; FREY H; REINHARDT S; SOHN J; BASTERT G;
Indirizzi:
UNIV HEIDELBERG,FRAUENKLIN,SEKT PRANATALE & GYNAKOL ULTRASCHALLDIAGNOST & TH,VOSSSTR 9 D-69115 HEIDELBERG GERMANY SONOTRON DIASON GARCHING GERMANY
Titolo Testata:
Radiologe
fascicolo: 8, volume: 37, anno: 1997,
pagine: 643 - 650
SICI:
0033-832X(1997)37:8<643:BDOBUI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
GER
Soggetto:
COLOR-DOPPLER;
Keywords:
BREAST TUMORS; BLOOD FLOW; BLOOD PRESSURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
C. Sohn et al., "BLOOD-FLOW DIAGNOSTICS OF BREAST-TUMORS UNDER INCREASED BLOOD-PRESSURE - NEW POSSIBILITIES IN ESTABLISHING THE NATURE OF THE TUMOR", Radiologe, 37(8), 1997, pp. 643-650

Abstract

On the assumption that the architecture of blood vessels of malignanttumors, formed by neoangiogenesis, shows characteristics that are different from those of blood vessels of benign tumors or physiological findings, we have tried in the present study to investigate the behavior of these different vessels under increased blood pressure. Using a special stand, the same sonographic section could be stably maintained during an examination time of approx. 4 minutes. Using a new computer program, the color pixels of the employed Angio color technique were quantified and recorded as a function of the measured blood pressure. To increase blood pressure, the patient had to press a hand grip, whichpractically always caused a systolic blood pressure elevation of morethan 15-20 mmHg. Seventy patients with sonographically detected breast tumors were examined; 54 (14 benign and 40 malignant tumors) could be included in the evaluation. We found four typical types of curves: Curve type 1 is associated with an instantaneous increase in blood flowwith increased blood pressure, followed by a drop in the blood pressure, with a slow decrease in blood flow as the blood pressure drops (with 29 malignant and 3 benign tumors). Curve type 2 shows a continuous increase in blood flow - though somewhat delayed with respect to the rise in blood pressure - which is also observed when the blood pressuredrops (exclusively benign tumors). In curve type 3, maximum blood flow is reached after the blood pressure maximum, and then the blood flowdecreases (1 benign and 3 malignant tumors). Curve type 4 features decreased blood flow in spite of increased blood pressure (3 benign and 5 malignant tumors). The described quantification method, in combination with the stand, permits for the first time analysis of a tumor under increased blood pressure as to its blood flow behavior over time in an examination using a challenge test. Here one can find two distinctive curve types (types 1 and 2) that correlate mostly with malignant (type 1) or benign (type 2) breast tumors. Should this tendency be substantiated by additional large-scale studies, it would seem that a new ultrasonic possibility for differential diagnosis has been found.

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Documento generato il 13/07/20 alle ore 04:42:04