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Titolo:
IL-13 OVER-EXPRESSION IN SKIN IS NOT CONFINED TO IGE-MEDIATED SKIN INFLAMMATION
Autore:
VANDERPLOEG I; TEHRANI MJ; MATUSEVICIENE G; WAHLGREN CF; FRANSSON J;
Indirizzi:
KAROLINSKA HOSP,DEPT LAB MED,DIV CLIN IMMUNOL S-17176 STOCKHOLM SWEDEN KAROLINSKA HOSP & INST,DEPT LAB MED,DIV CLIN IMMUNOL STOCKHOLM SWEDEN KAROLINSKA HOSP & INST,DEPT EAR EYE & SKIN,DIV DERMATOL & VENEREOL STOCKHOLM SWEDEN
Titolo Testata:
Clinical and experimental immunology
fascicolo: 3, volume: 109, anno: 1997,
pagine: 526 - 532
SICI:
0009-9104(1997)109:3<526:IOISIN>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; MESSENGER-RNA EXPRESSION; T-CELL CLONES; ATOPIC-DERMATITIS; INTERFERON-GAMMA; ALLERGEN CHALLENGE; CYTOKINE PROFILES; IN-SITU; B-CELLS; INTERLEUKIN-13;
Keywords:
COMPETITIVE RT-PCR; IMMUNOHISTOCHEMISTRY; SKIN; T CELLS; IL-13;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
I. Vanderploeg et al., "IL-13 OVER-EXPRESSION IN SKIN IS NOT CONFINED TO IGE-MEDIATED SKIN INFLAMMATION", Clinical and experimental immunology, 109(3), 1997, pp. 526-532

Abstract

IL-13 is produced by T cells and, like IL-4, it can induce the production of IgE and IgG4. In order to investigate if IL-13 is a specific marker for atopic dermatitis (AD), IL-13 gene expression was analysed in chronic lichenified lesions and non-lesional skin of patients with AD, in involved and non-involved skin of patients with psoriasis, in positive tuberculin reactions in non-atopics, and in the skin of healthycontrol subjects. Patients with AD (n = 9) showed sensitization to common air-borne allergens (positive Phadiatop) and had total serum IgE values in the range from 10 to 4800kU/l (median 170kU/l). Competitive reverse transcription-polymerase chain reaction (RT-PCR) was used to assess IL-13 gene expression in skin biopsy specimens. IL-13 gene expression was markedly higher in chronic lichenified lesions of patients with AD (P < 0.01), and in the positive tuberculin reactions (P < 0.01;n = 12)than in skin from healthy control subjects (n = 10). However, there was no significant difference in IL-13 gene expression in the skin of patients with psoriasis (n = 10) and that of healthy control subjects. The dermal cell infiltrates were larger and the relative amountof CD3(+) and CD4(+) cells in these infiltrates was higher in the skin of subjects with a positive tuberculin reaction than in lichenified AD skin. However, these differences were not reflected in differences in IL-13 gene expression. Different triggers of IL-13 gene expression may influence the diverse patterns of inflammation seen in different inflammatory skin disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 03:47:01