Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
METHODS FOR THE ANALYSIS OF THE NEW VINCA ALKALOID DERIVATIVE, S-12363, IN PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH FLUORESCENCE DETECTION
Autore:
GORDON BH; BAKES DM; BENNETT P; LEBRAS B; WALTHER B; LUCAS C; MARC S; GOUYETTE A;
Indirizzi:
SERVIER RES & DEV LTD,FULMER HALL,WINDMILL RD SLOUGH SL3 6HH BERKS ENGLAND INST RECH INT SERVIER F-92415 COURBEVOIE FRANCE INST GUSTAVE ROUSSY VILLEJUIF FRANCE
Titolo Testata:
Journal of chromatography B. Biomedical applications
fascicolo: 1, volume: 657, anno: 1994,
pagine: 163 - 171
Fonte:
ISI
Lingua:
ENG
Soggetto:
INVITRO PHARMACOKINETICS; VINBLASTINE; VINCRISTINE; RETENTION; CELLS; VINCAALKALOIDS; SENSITIVITY; XENOGRAFTS; METABOLISM; TOXICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
B.H. Gordon et al., "METHODS FOR THE ANALYSIS OF THE NEW VINCA ALKALOID DERIVATIVE, S-12363, IN PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH FLUORESCENCE DETECTION", Journal of chromatography B. Biomedical applications, 657(1), 1994, pp. 163-171

Abstract

Two sensitive analytical methods for the analysis of S 12363 in plasma are described. A highly sensitive procedure for human and dog plasmausing cyanopropyl solid-phase extraction with ion pairing chromatography and fluorescence detection, has a limit of quantification of 0.1 ng ml(-1). The technique has an overall precision and accuracy of 4.8 and 5.4% respectively over the concentration range 0.1-20 ng ml(-1). A second, less sensitive, assay specifically adapted for rodent plasma, uses benzene sulphonyl cation-exchange solid-phase extraction followedby reversed-phase chromatography, with post-column fluorescence enhancement. This method has a limit of quantitation of 1.0 ng ml(-1), withoverall accuracy and precision of 7.2 and 11.6% respectively, over the concentration range 1.0-20.0 ng ml(-1). Both assays have been successfully applied to dog and mouse toxicokinetic studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:40:18