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Titolo:
INHIBITORY EFFECT OF CALCITONIN-GENE-RELATED PEPTIDE ON MYOMETRIAL CONTRACTILITY IS DIMINISHED AT PARTURITION
Autore:
NAGHASHPOUR M; ROSENBLATT MI; DICKERSON IM; DAHL GP;
Indirizzi:
UNIV MIAMI,SCH MED,DEPT PHYSIOL & BIOPHYS R430,POB 016430 MIAMI FL 33101 UNIV MIAMI,SCH MED,DEPT PHYSIOL & BIOPHYS R430 MIAMI FL 33101
Titolo Testata:
Endocrinology
fascicolo: 10, volume: 138, anno: 1997,
pagine: 4207 - 4214
SICI:
0013-7227(1997)138:10<4207:IEOCPO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
XENOPUS-OOCYTES; UTERINE CONTRACTION; OXYTOCIN RECEPTORS; RAT UTERUS; IDENTIFICATION; RESPONSIVENESS; EXPRESSION; PREGNANCY; PROTEIN; NERVES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
M. Naghashpour et al., "INHIBITORY EFFECT OF CALCITONIN-GENE-RELATED PEPTIDE ON MYOMETRIAL CONTRACTILITY IS DIMINISHED AT PARTURITION", Endocrinology, 138(10), 1997, pp. 4207-4214

Abstract

The uterus is innervated by calcitonin gene-related peptide (CGRP) immunoreactive neurons, and CGRP inhibits spontaneous and evoked contractions in the uterus and fallopian tubes. In the present study using isometric force measurements on myometrial strips, we determined that CGRP inhibition of acetylcholine-induced contractions was drastically reduced at parturition compared with earlier stages of pregnancy in mice. The levels of inhibition exerted by CGRP paralleled the expression of a navel protein recently implicated in CGRP receptor activation, theCGRP-receptor component protein (CGRP-RCP). The mouse CGRP-RCP complementary DNA was isolated from uterus, and expression of the CGRP-RCP was monitored during gestation by Northern and Western blot analysis. Although CGRP-RCP messenger RNA levels did not vary significantly during gestation and postpartum, CGRP-RCP protein was greatly diminished atparturition. This diminution correlated with the loss of CGRP inhibition of acetylcholine-induced contractions observed in the force experiments. A role for CGRP and CGRP-RCP in modulation of myometrial smoothmuscle contractility during pregnancy and in labor is suggested.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 07:29:13