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Titolo:
ON THE MECHANISM(S) OF CHOLECYSTOKININ (CCK) - RECEPTOR STIMULATION ATTENUATES MORPHINE-DEPENDENCE IN MICE
Autore:
REZAYAT M; AZIZI N; ZARRINDAST MR;
Indirizzi:
TEHRAN UNIV MED SCI,SCH MED,DEPT PHARMACOL,POB 13145-784 TEHRAN IRAN TEHRAN UNIV MED SCI,SCH MED,DEPT PHARMACOL TEHRAN IRAN SOHA RES & DEV CTR TEHRAN IRAN
Titolo Testata:
Pharmacology & toxicology
fascicolo: 3, volume: 81, anno: 1997,
pagine: 124 - 129
SICI:
0901-9928(1997)81:3<124:OTMOC(>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
NALOXONE-PRECIPITATED WITHDRAWAL; ANTAGONIST L-365,260; DOPAMINE-RECEPTORS; NUCLEUS-ACCUMBENS; OCTAPEPTIDE CCK-8; RAT; BRAIN; AMPHETAMINE; ANALGESIA; TOLERANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
M. Rezayat et al., "ON THE MECHANISM(S) OF CHOLECYSTOKININ (CCK) - RECEPTOR STIMULATION ATTENUATES MORPHINE-DEPENDENCE IN MICE", Pharmacology & toxicology, 81(3), 1997, pp. 124-129

Abstract

In the present study, effect of cholecystokinin (CCK) agonists and ondependence to morphine in mice has been investigated. The influence of dopaminergic, adrenergic, cholinergic and serotonergic on attenuation of naloxone-induced jumping in morphine-dependent mice by CCK agonists were also considered. Mice were treated subcutaneously with morphine (50, 50 and 75 mg/kg) three times daily (10 a.m. 1 p.m. and 4 p.m.) for 3 days, and a last dose of morphine (50 mg/kg) was administered onthe 4th day. Withdrawal syndrome (jumping) was precipitated by naloxone (5 mg/kg) which was administered intraperitoneally 2 hr after the last dose of morphine. To study effects of CCK receptor agonists, 10 injection of morphine (3 administrations each day) for dependence and a dose of 5 mg/kg of naloxone for withdrawal induction were employed. The CCK agonists CCK-8 (0.001-0.1 mg/kg), unsulfated CCK-8 (CCK-8U; 0.001-0.1 mg/kg) and caerulein (0.00001-0.01 mg/kg) were able to prevent withdrawal signs precipitated by naloxone (5 mg/kg). Sulpiride and pimozide increased response induced by CCK-8 agonists. The dopamine antagonists also attenuates jumping by themselves. SCH 23390 did not alter the CCK-8 effect, but decreased the jumping by itself. Phenoxybenzamine, propranolol, methysergide and atropine did not change the caerulein effect significantly. However, single administration of atropine increased and methysergide decreased jumping. It is concluded that CCK mechanism(s) may be involved in morphine dependence, and dopaminergic mechanism(s) may interact with CCK in attenuation of naloxone-induced jumping.

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Documento generato il 06/04/20 alle ore 06:34:29