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Titolo:
OLFACTORY-BULB RECOVERY AFTER EARLY SENSORY DEPRIVATION
Autore:
CUMMINGS DM; HENNING HE; BRUNJES PC;
Indirizzi:
UNIV VIRGINIA,NEUROSCI PROGRAM,102 GILMER HALL CHARLOTTESVILLE VA 22903 UNIV VIRGINIA,NEUROSCI PROGRAM CHARLOTTESVILLE VA 22903 UNIV VIRGINIA,DEPT PSYCHOL CHARLOTTESVILLE VA 22903
Titolo Testata:
The Journal of neuroscience
fascicolo: 19, volume: 17, anno: 1997,
pagine: 7433 - 7440
SICI:
0270-6474(1997)17:19<7433:ORAESD>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
TYROSINE-HYDROXYLASE EXPRESSION; UNILATERAL ODOR DEPRIVATION; NARIS OCCLUSION; RAT; NEURONS; NEUROGENESIS; PROLIFERATION; EPITHELIUM; GROWTH; SYSTEM;
Keywords:
NEURONAL REGENERATION; SENSORY DEPRIVATION; UNILATERAL NARIS CLOSURE; ROSTRAL MIGRATORY STREAM; BROMODEOXYURIDINE (BRDU); OLFACTORY BULB; DEVELOPMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
D.M. Cummings et al., "OLFACTORY-BULB RECOVERY AFTER EARLY SENSORY DEPRIVATION", The Journal of neuroscience, 17(19), 1997, pp. 7433-7440

Abstract

Olfactory bulbs retain the ability to acquire new neurons throughout life. Unilateral olfactory deprivation during the first postnatal month in rats results in a dramatic reduction in the size of the experimental olfactory bulb. Part of this reduction is attributable to the death of neurons and glia. To examine the regenerative capacity of the juvenile olfactory bulb, we developed a technique for reversible olfactory deprivation. Reversible blockade from postnatal day 1 (P1) to P20 orP30 results in reduced bulb volume and tyrosine hydroxylase immunostaining, and decreased depth in the olfactory mucosa. In another experiment, normal stimulation was restored for varying periods of time, and experimental and control bulb volumes were measured. Recovery of bulb size occurs after 40 d of normal stimulation. Rats injected with a thymidine analog to label dividing cells during the recovery period revealed that rescue results at least in part from the addition of new neurons and glia, Thus, cells born after the return of normal levels of environmental stimulation can replace some of the neurons and glia that are lost during olfactory deprivation. This system can be used to study mechanisms that underlie neuronal regeneration in the maturing mammalian brain.

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Documento generato il 21/09/20 alle ore 06:39:56