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Titolo:
EFFICACY OF A HIGH AND ACCELERATED DOSE OF HEPATITIS-B VACCINE IN ALCOHOLIC PATIENTS - A RANDOMIZED CLINICAL-TRIAL
Autore:
ROSMAN AS; BASU P; GALVIN K; LIEBER CS;
Indirizzi:
VET ADM MED CTR,CTR ALCOHOL RES & TREATMENT,130 W KINGSBRIDGE RD BRONX NY 10468 VET ADM MED CTR,CTR ALCOHOL RES & TREATMENT BRONX NY 10468 MT SINAI SCH MED BRONX NY 00000
Titolo Testata:
The American journal of medicine
fascicolo: 3, volume: 103, anno: 1997,
pagine: 217 - 222
SICI:
0002-9343(1997)103:3<217:EOAHAA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; COST-EFFECTIVENESS ANALYSIS; HEALTH-CARE WORKERS; HEMODIALYSIS-PATIENTS; IMMUNE-RESPONSE; IMMUNOGENICITY; NONRESPONDERS; STRATEGIES; NONRESPONSIVENESS; THYMOPENTIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
A.S. Rosman et al., "EFFICACY OF A HIGH AND ACCELERATED DOSE OF HEPATITIS-B VACCINE IN ALCOHOLIC PATIENTS - A RANDOMIZED CLINICAL-TRIAL", The American journal of medicine, 103(3), 1997, pp. 217-222

Abstract

PURPOSE: A randomized, double-blind trial was conducted to compare the efficacy of a high-dose versus standard-dose hepatitis B vaccine in alcoholic patients. PATIENTS AND METHODS: One hundred ten alcoholic patients were randomized to either receive the standard dose (20 mu g at0, 1, and 6 months) or a high dose (40 mu g at 0, 1, 2, and 6 months)of recombinant hepatitis B vaccine (Engerix-B(R)). Patients were monitored for relapse of drinking using self-report, serial serum carbohydrate deficient transferrin, and collateral verification. The final titer of antibody to hepatitis B surface antigen (anti-HBs) was obtained 12 months after the first vaccine dose; a seroconversion was defined as a titer greater than 10 mlU/ml. RESULTS: One hundred subjects completed the study; 10 of these had clinical or pathological evidence of cirrhosis. Thirty-six out of 48 (75%) of patients administered the high-dose regimen seroconverted compared with 24 of 52 (46%) in the standard dose group (P <0.005). The mean anti-HBs titer of the high dose group was significantly greater than of the standard dose group (76.4 versus 39.4 mlU/ml, P <0.01). Logistic regression demonstrated a significant effect on seroconversion for the vaccine dose (P <0.005) and serum albumin (P = 0.05) but not for the other variables such as race, age, drinking during the study, serum creatinine, arm muscle circumference,and cirrhosis. CONCLUSIONS: A high- and accelerated-dose regimen of hepatitis B improves the serological response in alcoholic patients. This regimen (currently recommended for hemodialysis patients) should now also be considered for patients with a history of alcoholism. (C) 1997 by Excerpta Medica, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 10:15:08