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Titolo:
CONCORDANCE OF COMMON MOVEMENT-DISORDERS AMONG FAMILIAL CASES
Autore:
RAJPUT AH; FENTON ME; GEORGE D; RAJPUT T; WILSON W; MCCULLOCH L;
Indirizzi:
ROYAL UNIV HOSP,DIV NEUROL,ROOM 1663,103 HOSP DR SASKATOON SK S7N 0W8CANADA UNIV SASKATCHEWAN,DIV NEUROL SASKATOON SK CANADA UNIV SASKATCHEWAN,DEPT PATHOL SASKATOON SK S7N 0W0 CANADA UNIV IOWA,DEPT NEUROL IOWA CITY IA 52242
Titolo Testata:
Movement disorders
fascicolo: 5, volume: 12, anno: 1997,
pagine: 747 - 751
SICI:
0885-3185(1997)12:5<747:COCMAF>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUTOSOMAL-DOMINANT PARKINSONISM; HYDROXYLASE GENE POLYMORPHISM; MONOAMINE-OXIDASE-B; ESSENTIAL TREMOR; HUNTINGTONS-DISEASE; ASSOCIATION; TRANSMISSION; DEMENTIA; DYSTONIA; LEVODOPA;
Keywords:
PARKINSONS DISEASE; MOVEMENT DISORDER CONCORDANCE; FAMILIAL MOVEMENT DISORDERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
A.H. Rajput et al., "CONCORDANCE OF COMMON MOVEMENT-DISORDERS AMONG FAMILIAL CASES", Movement disorders, 12(5), 1997, pp. 747-751

Abstract

Multicase families are frequently utilized in studies of movement disorders (MDs). We report families with two or more MD cases seen at theMovement Disorder Clinic, Saskatoon (MDCS). In 30% of the MD probands, there was either a history or documentation of at least one secondary MD case in the family. Only those MD cases that were seen at the MDCS were considered in this study. A total of 56 probands and 77 secondary MD cases were seen at the MDCS between 1968 and 1996. In 24 (31.2%)of the secondary cases, the diagnosis was different from that in the proband. In 46 families (82%), only one secondary case was seen, and the diagnosis was concordant with the proband in 71.7%. In the remaining 10 families with two or more secondary cases, the diagnosis was concordant in 64.5% of cases. The largest subgroup was Parkinson's disease(PD)-40 probands and 53 secondary cases. Of these secondary cases, 73.6% had PD. The concordance rate was 91% in essential tremor, but only12.5% if the proband had essential tremor + parkinsonism. Consideringthat a large proportion of secondary cases have a diagnosis discordant with the proband, we recommend that, wherever possible, MD diagnosisin secondary cases be based on clinical assessment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:06:10