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Titolo:
CYTOSOLIC PHOSPHOLIPASE A(2), CYCLO-OXYGENASES AND ARACHIDONATE IN HUMAN STOMACH TUMORS
Autore:
SOYDAN AS; GAFFEN JD; WEECH PK; TREMBLAY NM; KARGMAN S; ONEILL G; BENNETT A; TAVARES IA;
Indirizzi:
UNIV LONDON KINGS COLL,SCH MED & DENT,RAYNE INST,ACAD DEPT SURG,123 COLDHARBOUR LANE LONDON SE5 9NU ENGLAND UNIV LONDON KINGS COLL,SCH MED & DENT,RAYNE INST,ACAD DEPT SURG LONDON SE5 9NU ENGLAND MERCK FROSST CTR THERAPEUT RES DORVAL PQ H9R 4P8 CANADA
Titolo Testata:
European journal of cancer
fascicolo: 9, volume: 33, anno: 1997,
pagine: 1508 - 1512
SICI:
0959-8049(1997)33:9<1508:CPACAA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN COLON-CANCER; PROSTAGLANDIN G/H SYNTHASE-1; EXPRESSION; CELLS; CYCLOOXYGENASE-2; CARCINOMA; PROFILES; TISSUE; ENZYME;
Keywords:
HUMAN STOMACH TUMORS; CANCER; ARACHIDONATE; CPLA(2); COX-1; COX-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
A.S. Soydan et al., "CYTOSOLIC PHOSPHOLIPASE A(2), CYCLO-OXYGENASES AND ARACHIDONATE IN HUMAN STOMACH TUMORS", European journal of cancer, 33(9), 1997, pp. 1508-1512

Abstract

Human stomach tumours usually form more prostaglandins (PGs) than their associated normal mucosa/submucosa, but the mechanisms are not fully understood. The key enzymes are cytosolic phospholipase A(2) (cPLA(2), Mr 85000) and the cyclo-oxygenases (COXs) which exist in constitutive (COX-1) and inducible forms (COX-2). In human stomach tumours and associated macroscopically normal tissues, we determined the fatty acidcomposition by gas chromatography, amounts of cPLA(2), COX-1 and COX-2 by immunoblotting with specific antibodies and cPLA(2) enzyme activity using a tritiated substrate. Although compared to normal mucosa there was less arachidonate in tumours (P < 0.05), the arachidonate/totalfatty acid ratio was higher. Mean amounts of cPLA(2) and COX-1 and cPLA(2) activity were similar in tumours and normal mucosa. However, substantial amounts of COX-2 were found in the tumours but not in the mucosa, which may explain why many gastric tumours form increased amountsof PGs. (C) 1997 Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 07:07:41