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Title
EFFECTS OF FLAVONOIDS OF GINKGO-BILOBA ON PROLIFERATION OF HUMAN SKINFIBROBLAST
Author:
KIM SJ; LIM MH; CHUN IK; WON YH;
Addresses:
CHONNAM NATL UNIV,SCH MED,DEPT DERMATOL KWANGJU 501757 SOUTH KOREA
Heading Title:
Skin pharmacology
issue: 4, volume: 10, year: 1997,
pages: 200 - 205
SICI:
1011-0283(1997)10:4<200:EOFOGO>2.0.ZU;2-#
Source:
ISI
Language:
ENG
Subject:
PLATELET-ACTIVATING-FACTOR; DOUBLE-BLIND; ANTAGONIST; BN-52021; EXTRACT; MULTICENTER; TERPENES; CELLS;
Keywords:
GINKGO BILOBA; FIBROBLAST PROLIFERATION; FLAVONOIDS;
Document Type:
Article
Nature:
Serial
Citations:
18
Reviewed:
Addresses for extracts:
Citation:
S.J. Kim and others, "EFFECTS OF FLAVONOIDS OF GINKGO-BILOBA ON PROLIFERATION OF HUMAN SKINFIBROBLAST", Skin pharmacology, 10(4), 1997, pp. 200-205

Abstract

Ginkgo biloba studies have focused on the anti-inflammatory effects of the major components, ginkgolide and bilobalide, whereas little is known about their effect on fibroblasts. This study demonstrated the enhancing effects of Ginkgo L. extracts, especially the flavonoid fractions: quercetin, kaempferol, sciadopitysin, ginkgetin, isoginkgetin, onthe proliferation of normal human skin fibroblast in vitro measured by MTT ,5-dimethylthiazole-2-yl]-2,5-diphenyl-tetrazolium bromide) assay and direct hemocytometer cell count. Furthermore, increased production of collagen and extracellular fibronectin were documented by radioisotope (2,3-H-3-proline) incorporated collagen assay, procollagen typeI C-peptide assay and by immunoturbidimetric assay. These proliferative effects suggest another useful pharmacologic application of Ginkgo L. extracts in addition to their well-known anti-inflammatory effect.

ASDD Area Sistemi Dipartimentali e Documentali, Bologna University, Review Catalogue
Document created on 27/05/19 at 13:31:07