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Pre-menstrual steroids
CELLULAR AND MOLECULAR LIFE SCIENCES
Therapeutic potential of steroids for CNS disorders
EXPERT OPINION ON THERAPEUTIC PATENTS
Ventral tegmental area infusions of inhibitors of the biosynthesis and metabolism of 3 alpha,5 alpha-THP attenuate lordosis of hormone-primed and behavioural oestrous rats and hamsters
JOURNAL OF NEUROENDOCRINOLOGY
Progesterone and the oligodendroglial lineage: Stage-dependent biosynthesis and metabolism
GLIA
Clozapine, but not haloperidol, increases brain concentrations of neuroactive steroids in the rat
NEUROPSYCHOPHARMACOLOGY
[H-3]flunitrazepam binding to recombinant alpha(1)beta(2)gamma(2S) GABA(A)receptors stably expressed in HEK 293 cells
BIOMEDICINE & PHARMACOTHERAPY
Afferent baroreceptor discharge in pregnant rats
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
Effects of acute progesterone administration in healthy postmenopausal women and normally-cycling women
PSYCHONEUROENDOCRINOLOGY
Motherhood and memory: a review
PSYCHONEUROENDOCRINOLOGY
Neurosteroid-induced enhancement of glutamate transmission in rat hippocampal slices
NEUROSCIENCE LETTERS
Ontogeny of the neurosteroid enzyme Cyp7b in the mouse
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Heterogeneity of hippocampal GABA(A) receptors: Regulation by corticosterone
JOURNAL OF NEUROSCIENCE
3 alpha-hydroxy-5 alpha-pregnan-20-one levels and GABA(A) receptor-mediated Cl-36(-) flux across development in rat cerebral cortex
DEVELOPMENTAL BRAIN RESEARCH
Early postnatal ethanol intubation blunts GABA(A) receptor up-regulation and modifies 3 alpha-hydroxy-5 alpha-pregnan-20-one sensitivity in rat MS/DBneurons
DEVELOPMENTAL BRAIN RESEARCH
Allopregnanolone and pentobarbital infused into the nucleus accumbens substitute for the discriminative stimulus effects of ethanol
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
Inhibition of aggression by progesterone and its metabolites in female Syrian hamsters
AGGRESSIVE BEHAVIOR
Role of the peripheral-type benzodazepine receptor in adrenal and brain steroidogenesis
NEUROSTEROIDS AND BRAIN FUNCTION
GABA(A)-receptor plasticity during long-term exposure to and withdrawal from progesterone
NEUROSTEROIDS AND BRAIN FUNCTION
Unsulfated and sulfated neurosteroids differentially modulate the binding characteristics of various radioligands of GABA(A) receptors following chronic ethanol administration
NEUROPHARMACOLOGY
Anxiolytic effect of Kami-Shoyo-San (TJ-24) in mice - Possible mediation of neurosteroid synthesis
LIFE SCIENCES
Diminished allopregnanolone enhancement of GABA(A) receptor currents in a rat model of chronic temporal lobe epilepsy
JOURNAL OF PHYSIOLOGY-LONDON
Increased expression of the neuropeptide Y receptor Y-1 gene in the medialamygdala of transgenic mice induced by long-term treatment with progesterone or allopregnanolone
JOURNAL OF NEUROCHEMISTRY
Activity and localization of 3 beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4)-isomerase in the zebrafish central nervous system
JOURNAL OF COMPARATIVE NEUROLOGY
Brief exposure to female odors "emboldens" male mice by reducing predator-induced behavioral and hormonal responses
HORMONES AND BEHAVIOR
The role of neurosteroids and nongenomic effects of progestins in the ventral tegmental area in mediating sexual receptivity of rodents
HORMONES AND BEHAVIOR
Dehydroepiandrosterone in songbird plasma: Seasonal regulation and relationship to territorial aggression
GENERAL AND COMPARATIVE ENDOCRINOLOGY
The anxiolytic effect of allopregnanolone is associated with gonadal hormonal status in female rats
EUROPEAN JOURNAL OF PHARMACOLOGY
Effect of beta-estradiol on voltage-gated Ca2+ channels in rat hippocampalneurons: a comparison with dehydroepiandrosterone
EUROPEAN JOURNAL OF PHARMACOLOGY
Neurosteroid withdrawal model of perimenstrual catamenial epilepsy
EPILEPSIA
Enhanced anticonvulsant activity of neuroactive steroids in a rat model ofcatamenial epilepsy
EPILEPSIA
Testosterone reduces pentylenetetrazole-induced ictal activity of wildtypemice but not those deficient in type I 5 alpha-reductase
BRAIN RESEARCH
3 alpha,5 alpha-THP in the raphe magnus attenuates PTZ-induced myoclonic seizures
BRAIN RESEARCH
Short-term exposure to a neuroactive steroid increases alpha 4 GABA(A) receptor subunit levels in association with increased anxiety in the famale rat
BRAIN RESEARCH
Cataleptic effect of neurosteroid 3 alpha-hydroxy-5 alpha-pregnan-20-one in mice: modulation by serotonergic agents
BRAIN RESEARCH
Alcohol, allopregnanolone and aggression in mice
PSYCHOPHARMACOLOGY
Pathways of dehydroepiandrosterone formation in rat brain glia
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
Ganaxolone for treating intractable infantile spasms: a multicenter, open-label, add-on trial
EPILEPSY RESEARCH
Progesterone and testosterone modulate the convulsant actions of pentylenetetrazol and strychnine in mice
PHARMACOLOGY & TOXICOLOGY
Anti-seizure effects of progesterone and 3 alpha,5 alpha-THP in kainic acid and perforant pathway models of epilepsy
PSYCHONEUROENDOCRINOLOGY
Antinociceptive effects of the neuroactive steroid, 3 alpha-hydroxy-5 alpha-pregnan-20-one and progesterone in the land snail, Cepaea nemoralis
NEUROSCIENCE
Antinociceptive properties of neurosteroids II. Experiments with Saffan (R) and its components alphaxalone and alphadolone to reveal separation of anaesthetic and antinociceptive effects and the involvement of spinal cord GABA(A) receptors
PAIN
Effects of neurosteroids on Ca2+ signaling mediated by recombinant N-methyl-D-aspartate receptor expressed in Chinese hamster ovary cells
NEUROSCIENCE LETTERS
Non-competitive inhibition of 5-HT3 receptor-mediated currents by progesterone in rat nodose ganglion neurons
NEUROSCIENCE LETTERS
Neurosteroid modulation of GABA IPSCs is phosphorylation dependent
JOURNAL OF NEUROSCIENCE
Slow death of postnatal hippocampal neurons by GABA(A) receptor overactivation
JOURNAL OF NEUROSCIENCE
Progesterone as a neuroactive neurosteroid, with special reference to the effect of progesterone on myelination
HUMAN REPRODUCTION
Anti-sense oligonucleotides, for progestin receptors in the VMH and glutamic acid decarboxylase in the VTA, attenuate progesterone-induced lordosis in hamsters and rats
BEHAVIOURAL BRAIN RESEARCH
Long-term plasticity of postsynaptic GABA(A)-receptor function in the adult brain: insights from the oxytocin neurone
TRENDS IN NEUROSCIENCES
Central allopregnanolone is increased in rat pups in response to repeated,short episodes of neonatal isolation
DEVELOPMENTAL BRAIN RESEARCH
Localization of P450scc and 5 alpha-reductase type-2 in the cerebellum of fetal and newborn sheep
DEVELOPMENTAL BRAIN RESEARCH
Developmental switch in the expression of GABA(A) receptor subunits alpha(1) and alpha(2) in the hypothalamus and limbic system of the rat
DEVELOPMENTAL BRAIN RESEARCH
Acute neuroactive steroid withdrawal in withdrawal seizure-prone and withdrawal seizure-resistant mice
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
Effect of epipregnanolone and pregnenolone sulfate on chronic tolerance toethanol
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
Effects of benzodiazepine receptor ligands and ethanol in rats trained to discriminate pregnanolone
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
Estrous cycle and sex differences in performance on anxiety tasks coincidewith increases in hippocampal progesterone and 3 alpha,5 alpha-THP
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
Neurosteroids and reward: allopregnanolone produces a conditioned place aversion in rats
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
Antidepressant-like effect of the neurosteroid 3 alpha-hydroxy-5 alpha-pregnan-20-one in mice forced swim test
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
Caffeine-induced increases in the brain and plasma concentrations of neuroactive steroids in the rat
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
Progesterone as a neuroactive neurosteroid, with special reference to the effect of progesterone on myelination
STEROIDS
High doses of systemic DHEA-sulfate do not affect sleep structure and elicit moderate changes in non-REM sleep EEG in rats
PHYSIOLOGY & BEHAVIOR
Modulation of GABAergic synaptic transmission by the non-benzodiazepine anxiolytic etifoxine
NEUROPHARMACOLOGY
Steroidogenesis in rat brain induced by short- and long-term administration of carbamazepine
NEUROPHARMACOLOGY
Allopregnanolone synthesis in cerebellar granule cells: Roles in regulation of GABA(A) receptor expression and function during progesterone treatmentand withdrawal
MOLECULAR PHARMACOLOGY
Enantioselectivity of pregnanolone-induced gamma-aminobutyric acid(A) receptor modulation and anesthesia
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Differential change in neuroactive steroid sensitivity during ethanol withdrawal
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Conformationally constrained anesthetic steroids that modulate GABA(A) receptors
JOURNAL OF MEDICINAL CHEMISTRY
Dimorphic features of the different alpha-containing GABA-A receptor subtypes in the cortico-basal ganglia system of two distantly related mammals (hedgehog and rat)
EXPERIMENTAL BRAIN RESEARCH
3 alpha-Hydroxy-5 alpha-pregnan-20-one exposure reduces GABA(A) receptor alpha 4 subunit mRNA levels
EUROPEAN JOURNAL OF PHARMACOLOGY
Expression of 5 alpha-reductase and 3 alpha-hydroxisteroid oxidoreductase in the hippocampus of patients with chronic temporal lobe epilepsy
EPILEPSIA
Infusion of 3 alpha,5 alpha-THP to the pontine reticular formation attenuates PTZ-induced seizures
BRAIN RESEARCH
Neurosteroid modulation of embryonic neuronal survival in vitro following anoxia
BRAIN RESEARCH
The effect of steroid sulfatase inhibition on learning and spatial memory
BRAIN RESEARCH
Serotonergic agents modulate antidepressant-like effect of the neurosteroid 3 alpha-hydroxy-5 alpha-pregnan-20-one in mice
BRAIN RESEARCH
Prolonged intracerebroventricular infusion of neurosteroids affects cognitive performances in the mouse
BRAIN RESEARCH
Pregnenolone sulfate increases hippocampal acetylcholine release and spatial recognition
BRAIN RESEARCH
Olanzapine increases allopregnanolone in the rat cerebral cortex
BIOLOGICAL PSYCHIATRY
Plasma membrane receptors for the cancer-regulating progesterone metabolites, 5 alpha-pregnane-3,20-dione and 3 alpha-hydroxy-4-pregnen-20-one in MCF-7 breast cancer cells
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Activation of peripheral mitochondrial benzodiazepine receptors in the hippocampus stimulates allopregnanolone synthesis and produces anxiolytic-likeeffects in the rat
PSYCHOPHARMACOLOGY
Neuroactive steroids attenuate cocaine-induced sucrose intake in rats, butnot cocaine-induced hyperactivity in mice
PSYCHOPHARMACOLOGY
Distress vocalizations in maternally separated mouse pups: modulation via 5-HT1A, 5-HT1B and GABA(A) receptors
PSYCHOPHARMACOLOGY
Can the insect nervous system synthesize ecdysteroids?
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
An investigation of endogenous neuroactive steroid-induced modulation of ethanol's discriminative stimulus effects
BEHAVIOURAL PHARMACOLOGY
Quantitative determination of pregnenolone 3-sulfate in rat brains using liquid chromatography/electrospray ionization-mass spectrometry
ANALYTICAL SCIENCES
Neuroactive neurosteroids: dehydroepiandrosterone (DHEA) and DHEA sulphate
ACTA PAEDIATRICA
3 alpha,5 alpha-THP in the midbrain ventral tegmental area of rats and hamsters is increased in exogenous hormonal states associated with estrous cyclicity and sexual receptivity
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
Localisation of dehydroepiandrosterone sulphotransferase in adult rat brain
BRAIN RESEARCH BULLETIN
Neurosteroid regulation of inhibitory synaptic transmission in the rat hippocampus in vitro
NEUROSCIENCE
Neurosteroid modulation of dendrodendritic inhibition in the mouse olfactory bulb
NEUROSCIENCE LETTERS
Dehydroepiandrosterone (DHEA) protects hippocampal cells from oxidative stress-induced damage
MOLECULAR BRAIN RESEARCH
Widespread expression of GABA(A) receptor subunits in peripheral tissues
NEUROSCIENCE RESEARCH
The amygdala mediates the anxiolytic-like effect of the neurosteroid allopregnanolone in rat
BEHAVIOURAL BRAIN RESEARCH
GABA(A), D-1, and D-5, but not progestin receptor, antagonist and anti-sense oligonucleotide infusions to the ventral tegmental area of cycling rats and hamsters attenuate lordosis
BEHAVIOURAL BRAIN RESEARCH
Endogenous levels of 5 alpha-reduced progestins and androgens in fetal vs.adult rat brains
DEVELOPMENTAL BRAIN RESEARCH
Neurosteroid modulation of the GABA(A) receptor in the developing guinea pig cerebral cortex
DEVELOPMENTAL BRAIN RESEARCH
An update on GABA(A) receptors
BRAIN RESEARCH REVIEWS
Sex-dependent behavioral effects of the neurosteroid allopregnanolone (3 alpha,5 alpha-THP) in neonatal and adult rats after postnatal stress
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
Progesterone in conjunction with estradiol has neuroprotective effects in an animal model of neurodegeneration
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
Reduced progesterone metabolites are not critical for plus-maze performance of lactating female rats
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
Cyclic withdrawal from endogenous and exogenous progesterone increases kainic acid and perforant pathway induced seizures
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
Attenuated sensitivity to neuroactive steroids in gamma-aminobutyrate typeA receptor delta subunit knockout mice
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA