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Overexpression of cyclin E and cyclin-dependent kinase 2 is correlated with development of hepatocellular carcinomas
HEPATOLOGY RESEARCH
Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with PhosphoCDK2
MOLECULAR CELL
Regulation of the cell cycle by B-Myb
BLOOD CELLS MOLECULES AND DISEASES
Regulation of the cell cycle by B-Myb
BLOOD CELLS MOLECULES AND DISEASES
Cyclin E mRNA overexpression in epithelial ovarian cancers: Inverse correlation with p53 protein accumulation
JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION
Estrogens and cell-cycle regulation in breast cancer
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Cell cycle in the Fucus zygote parallels a somatic cell cycle but displaysa unique translational regulation of cyclin-dependent kinases
PLANT CELL
IFN alpha 2b induces apoptosis and proteasome-mediated degradation of p27(Kip1) in a human lung cancer cell line
ONCOLOGY REPORTS
Overexpression of SCC antigen and cyclins in an adenoid squamous carcinomacell line derived from the maxillary sinus
INTERNATIONAL JOURNAL OF ONCOLOGY
Role for cyclin-dependent kinase 2 in mitosis exit
CURRENT BIOLOGY
No evidence of a role for activating CDK2 mutations in melanoma
MELANOMA RESEARCH
Difference in the centrosome duplication regulatory activity among p53 'hot spot' mutants: potential role of Ser 315 phosphorylation-dependent centrosome binding of p53
ONCOGENE
E1A modulates phosphorylation of p130 and p107 by differentially regulating the activity of G1/S cyclin/CDK complexes
ONCOGENE
Direct regulation of the centrosome duplication cycle by the p53-p21(Waf1/Cip1) pathway
ONCOGENE
Stem cells and the regulation of proliferation, differentiation and patterning in the intestinal epithelium: emerging insights from gene expression patterns, transgenic and gene ablation studies
MECHANISMS OF DEVELOPMENT
Overexpression of CDK2 is a prognostic indicator of oral cancer progression
JAPANESE JOURNAL OF CANCER RESEARCH
Anticarcinogenic effect and enhancement of metastatic potential of BALB/c 3T3 cells by ginsenoside Rh-2
JAPANESE JOURNAL OF CANCER RESEARCH
Immunohistochemical expression of cell cycle proteins E2F-1, Cdk-2, cyclinE, p27(kip1), and Ki-67 in normal placenta and gestational trophoblastic disease
MODERN PATHOLOGY
E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis
GENES & DEVELOPMENT
Checkpoints for vesicular traffic?
BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE
Chemically induced rat mammary tumor treated with tamoxifen showed decreased expression of cyclin D1, cyclin E, and p21(Cip1)
CANCER LETTERS
The genomic structure of two protein kinase CK2 alpha genes of Xenopus laevis and features of the putative promoter region
MOLECULAR AND CELLULAR BIOCHEMISTRY
The mechanism of protein kinase regulation by protein phosphatases
BIOCHEMICAL SOCIETY TRANSACTIONS
Differential regulation of retinoblastoma tumor suppressor protein by G(1)cyclin-dependent kinase complexes in vivo
MOLECULAR AND CELLULAR BIOLOGY
A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and Cyclin A-Cdk2 during cell cycle progression
MOLECULAR AND CELLULAR BIOLOGY
Complex regulation of CDK2 and g1 arrest during neuronal differentiation of human prostatic cancer TSU-Pr1 cells by staurosporine
ANTICANCER RESEARCH
Polyamine depletion arrests growth of IEC-6 and Caco-2 cells by different mechanisms
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
Inhibition of human breast cancer cell growth by blockade of the mevalonate-protein prenylation pathway is not prevented by overexpression of cyclin D1
BREAST CANCER RESEARCH AND TREATMENT
Preliminary cryocrystallography analysis of an eumenine mastoparan toxin isolated from the venom of the wasp Anterhynchium flavomarginatum micado
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY
The CRK3 protein kinase is essential for cell cycle progression of Leishmania Mexicana
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
Activation of cyclin E-dependent kinase activity in colorectal cancer
DIGESTIVE DISEASES AND SCIENCES
The role of p27 in endometrial carcinoma
GYNECOLOGIC ONCOLOGY
Expression of cyclins E1 and E2 during mouse development and in neoplasia
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Iron deficiency alters the progression of mitogen-treated murine splenic lymphocytes through the cell cycle
JOURNAL OF NUTRITION
Crystal structure of human cyclin-dependent kinase 2 in complex with the adenine-derived inhibitor H717
JOURNAL OF MEDICINAL CHEMISTRY
Mechanism for the transcriptional repression by c-Myc on PDGF beta-receptor
JOURNAL OF CELL SCIENCE
Localization of two mammalian cyclin dependent kinases during mammalian meiosis
JOURNAL OF CELL SCIENCE
Phosphorylation of the CCAAT displacement protein (CDP)/Cux transcription factor by cyclin A-cdk1 modulates its DNA binding activity in G(2)
JOURNAL OF BIOLOGICAL CHEMISTRY
Constitutive MEK/MAPK activation leads to p27(Kip1) deregulation and antiestrogen resistance in human breast cancer cells
JOURNAL OF BIOLOGICAL CHEMISTRY
Characterization of an N-terminally truncated cyclin a isoform in mammalian cells
JOURNAL OF BIOLOGICAL CHEMISTRY
Identification of an estrogen-inducible phosphatase (PP5) that converts MCF-7 human breast carcinoma cells into an estrogen-independent phenotype when expressed constitutively
JOURNAL OF BIOLOGICAL CHEMISTRY
Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/P25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease - A property common to most cycline-dependent kinase inhibitors?
JOURNAL OF BIOLOGICAL CHEMISTRY
Immunoreactivity for p27(kip1) and cyclin E is an independent predictor ofsurvival in primary gastric non-Hodgkin's lymphoma
INTERNATIONAL JOURNAL OF CANCER
A genetic screen for suppressors and enhancers of the Drosophila PAN GU cell cycle kinase identifies cyclin B as a target
GENETICS
Characterization of adriamycin-induced G2 arrest and its abrogation by caffeine in FL-amnion cells with or without p53
EXPERIMENTAL CELL RESEARCH
The role of Thr160 phosphorylation of Cdk2 in substrate recognition
EUROPEAN JOURNAL OF BIOCHEMISTRY
Cyclin E is the only cyclin-dependent kinase 2-associated cyclin that predicts metastasis and survival in early stage non-small cell lung cancer
CANCER RESEARCH
A novel cdk2-selective inhibitor, SU9516, induces apoptosis in colon carcinoma cells
CANCER RESEARCH
AIB1 enhances estrogen-dependent induction of cyclin D1 expression
CANCER RESEARCH
Up-regulation of cyclin-dependent kinase 4/Cyclin d2 expression but down-regulation of cyclin-dependent kinase 2/cyclin E in testicular germ cell tumors
CANCER RESEARCH
Structure-activity relationships and inhibitory effects of various purine derivatives on the in vitro growth of Plasmodium falciparum
BIOCHEMICAL PHARMACOLOGY
Stimulation of DNA polymerase alpha activity by Cdk2-phosphorylated Rb protein
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
The F-box protein SKP2 binds to the phosphorylated threonine 380 in cyclinE and regulates ubiquitin-dependent degradation of cyclin E
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Purine analogs as CDK enzyme inhibitory agents: A survey and QSAR analysis
PROGRESS IN DRUG RESEARCH, VOL 56
Cyclin-dependent kinases inhibitors as potential anticancer, antineurodegenerative, antiviral and antiparasitic agents
DRUG RESISTANCE UPDATES
Adenovirus-mediated E2F-1 gene transfer induces an apoptotic response in human gastric carcinoma cells that is enhanced by cyclin dependent kinase inhibitors
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
Initiation of eukaryotic DNA replication: Origin unwinding and sequential chromatin association of Cdc45, RPA, and DNA polymerase alpha
MOLECULAR CELL
Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors
CHEMISTRY & BIOLOGY
Inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis
CELL GROWTH & DIFFERENTIATION
Retinoic acid induces neuronal differentiation of embryonal carcinoma cells by reducing proteasome-dependent proteolysis of the cyclin-dependent inhibitor p27
CELL GROWTH & DIFFERENTIATION
Xenopus ATR is a replication-dependent chromatin-binding protein required for the DMA replication checkpoint
CURRENT BIOLOGY
Involvement of p27(Kip1) in G1 arrest by high dose 5 alpha-dihydrotestosterone in LNCaP human prostate cancer cells
ONCOGENE
[Lys(61)]N-Ras is able to induce full activation and nuclear accumulation of Cdk4 in NIH3T3 cells
ONCOGENE
Reduction of Cdc25A contributes to cyclin E1-Cdk2 inhibition at senescencein human mammary epithelial cells
ONCOGENE
Reversal of an antiestrogen-mediated cell cycle arrest of MCF-7 cells by viral tumor antigens requires the retinoblastoma protein-binding domain
ONCOGENE
Cdk2 associates with MAP kinase in vivo and its nuclear translocation is dependent on MAP Kinase activation in IL-2-dependent Kit 225 T lymphocytes
ONCOGENE
A genetic screen to identify genes that rescue the slow growth phenotype of c-myc null fibroblasts
ONCOGENE
Synergistic induction of centrosome hyperamplification by loss of p53 and cyclin E overexpression
ONCOGENE
Overexpression of DA41 in v-Ha-ras-3Y1 cells causes growth suppression
JAPANESE JOURNAL OF CANCER RESEARCH
The carcinogen 2-acetylaminofluorene inhibits activation and nuclear accumulation of cyclin-dependent kinase 2 in growth-induced rat liver
MOLECULAR CARCINOGENESIS
NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription
GENES & DEVELOPMENT
Cell cycle arrest induced by ectopic expression of p27 is not sufficient to promote oligodendrocyte differentiation
JOURNAL OF CELLULAR BIOCHEMISTRY
Characterization and targeted disruption of murine Nup50, a p27(Kip1)-interacting component of the nuclear pore complex
MOLECULAR AND CELLULAR BIOLOGY
Involvement of Myc activity in a G(1)/S-promoting mechanism parallel to the pRb/E2F pathway
MOLECULAR AND CELLULAR BIOLOGY
Cell cycle control of Schwann cell proliferation: Role of cyclin-dependentkinase-2
JOURNAL OF NEUROSCIENCE
Imidazo[2,1-b]thiazolylmethylene- and indolylmethylene-2-indolinones: a new class of cyclin-dependent kinase inhibitors. Design, synthesis, and CDK1/cyclin B inhibition
ANTI-CANCER DRUG DESIGN
Structure-based design modifications of the paullone molecular scaffold for cyclin-dependent kinase inhibition
ANTI-CANCER DRUG DESIGN
Expression of the E2F family of transcription factors during murine development
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
Cyclin D1 overexpression in a model of human breast premalignancy: preferential stimulation of anchorage-independent but not anchorage-dependent growth is associated with increased cdk2 activity
BREAST CANCER RESEARCH AND TREATMENT
Nebivolol inhibits human aortic smooth muscle cell growth: Effects on cellcycle regulatory proteins
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
Telomerase activity correlates with cell cycle regulators in human hepatocellular carcinoma
LIVER
Herpes simplex virus type 1 infection imposes a G(1)/S block in asynchronously growing cells and prevents G(1) entry in quiescent cells
VIROLOGY
A chemical switch for inhibitor-sensitive alleles of any protein kinase
NATURE
Expression patterns of p27(Kip1) and Ki-67 in cholesteatoma epithelium
LARYNGOSCOPE
p27(kip1) expression in rectal cancer correlates with disease-free survival
JOURNAL OF SURGICAL RESEARCH
Cyclin-dependent kinase inhibition by new C-2 alkynylated purine derivatives and molecular structure of a CDK2-inhibitor complex
JOURNAL OF MEDICINAL CHEMISTRY
Pyrido[2,3-d]pyrimidin-7-one inhibitors of cyclin-dependent kinases
JOURNAL OF MEDICINAL CHEMISTRY
3D-QSAR CoMFA on cyclin-dependent kinase inhibitors
JOURNAL OF MEDICINAL CHEMISTRY
Thio- and oxoflavopiridols, cyclin-dependent kinase 1-selective inhibitors: Synthesis and biological effects
JOURNAL OF MEDICINAL CHEMISTRY
Docking-based development of purine-like inhibitors of cyclin-dependent kinase-2
JOURNAL OF MEDICINAL CHEMISTRY
Binding mode of the 4-anilinoquinazoline class of protein kinase inhibitor: X-ray crystallographic studies of 4-anilinoquinazolines bound to cyclin-dependent kinase 2 and p38 kinase
JOURNAL OF MEDICINAL CHEMISTRY
Cell cycle-dependent localization of the CDK3-cyclin E complex in Cajal (coiled) bodies
JOURNAL OF CELL SCIENCE
p21 and retinoblastoma protein control the absence of DNA replication in terminally differentiated muscle cells
JOURNAL OF CELL BIOLOGY
Caspase-dependent Cdk activity is a requisite effector of apoptotic death events
JOURNAL OF CELL BIOLOGY
The low M-r protein-tyrosine phosphatase is involved in Rho-mediated cytoskeleton rearrangement after integrin and platelet-derived growth factor stimulation
JOURNAL OF BIOLOGICAL CHEMISTRY
Caspase 3-mediated cleavage of p21(WAF1/CIP1) associated with the cyclin A-cyclin-dependent kinase 2 complex is a prerequisite for apoptosis in SK-HEP-1 cells
JOURNAL OF BIOLOGICAL CHEMISTRY
Induction of anchorage-independent growth by transforming growth factor-beta linked to anchorage-independent expression of cyclin D1
JOURNAL OF BIOLOGICAL CHEMISTRY
Correlation of cyclin D1 mRNA levels with clinico-pathological parameters and clinical outcome in human breast carcinomas
INTERNATIONAL JOURNAL OF CANCER
Cell cycle activation by c-myc in a Burkitt lymphoma model cell line
INTERNATIONAL JOURNAL OF CANCER
Inhibition of cell growth and apoptosis by inducible expression of the transcriptional repressor Mad1
EXPERIMENTAL CELL RESEARCH