Catalogo Articoli (Spogli Riviste)
OPAC HELP
Titolo: Concise synthesis of the C3-C14-fragment of the antitumor agent laulimalide. Application of Jacobsen's HKR reaction
Autore: Dorling, EK; Ohler, E; Mantoulidis, A; Mulzer, J;
- Indirizzi:
- Univ Vienna, Inst Organ Chem, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 nst Organ Chem, A-1090 Vienna, Austria
- Titolo Testata:
- SYNLETT
fascicolo: 7,
,
anno: 2001,
pagine: 1105 - 1108
- SICI:
- 0936-5214(200107):7<1105:CSOTCO>2.0.ZU;2-D
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- ENANTIOSELECTIVE SYNTHESIS; MACROLIDE LAULIMALIDE; SEGMENT; ALDEHYDES; FRAGMENT; TAXOL;
- Keywords:
- antitumor agents; epoxides; Jacobsen's HKR reaction; Eschenmoser methylenation;
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Physical, Chemical & Earth Sciences
- Citazioni:
- 26
- Recensione:
- Indirizzi per estratti:
- Indirizzo: Mulzer, J Univ Vienna, Inst Organ Chem, Wahringerstr 38, A-1090 Vienna, Austria Univ Vienna Wahringerstr 38 Vienna Austria A-1090 enna, Austria
-
-
-
- Citazione:
- E.K. Dorling et al., "Concise synthesis of the C3-C14-fragment of the antitumor agent laulimalide. Application of Jacobsen's HKR reaction", SYNLETT, (7), 2001, pp. 1105-1108
Abstract
Bromide 3, which represents an appropriately functionalized C3-C14-fragment of the antitumor agent laulimalide (1) has been synthesized from (-)-citronellal (4) in an overall yield of ca. 17% (12 isolated intermediates). At a very early stage, the synthesis makes use of Jacobsen's HKR reaction to produce epoxide 8 in diastereomerically pure form.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/05/13 alle ore 05:09:33