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Titolo:
Acemannan purified from Aloe vera induces phenotypic and functional maturation of immature dendritic cells
Autore:
Lee, JK; Lee, MK; Yun, YP; Kim, Y; Kim, JS; Kim, YS; Kim, K; Han, SS; Lee, CK;
Indirizzi:
Chungbuk Natl Univ, Coll Pharm, Cheongju 361763, South Korea Chungbuk NatlUniv Cheongju South Korea 361763 ongju 361763, South Korea Seoul Natl Univ, Inst Nat Prod Res, Seoul 110460, South Korea Seoul Natl Univ Seoul South Korea 110460 Res, Seoul 110460, South Korea Sahm Yook Univ, Dept Pharm, Seoul 139742, South Korea Sahm Yook Univ Seoul South Korea 139742 Pharm, Seoul 139742, South Korea
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 7, volume: 1, anno: 2001,
pagine: 1275 - 1284
SICI:
1567-5769(200107)1:7<1275:APFAVI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
MANNOSE RECEPTOR; MACROPHAGES; ANTIGEN; IMMUNOSTIMULANT; LYMPHOCYTES; ACTIVATION; GENERATION; GEL;
Keywords:
Aloe vera; acemannan; dendritic cell; differentiation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, CK Chungbuk Natl Univ, Coll Pharm, Cheongju 361763, South Korea Chungbuk Natl Univ Cheongju South Korea 361763 1763, South Korea
Citazione:
J.K. Lee et al., "Acemannan purified from Aloe vera induces phenotypic and functional maturation of immature dendritic cells", INT IMMUNO, 1(7), 2001, pp. 1275-1284

Abstract

Acemannan, a major carbohydrate fraction of Aloe vera gel, has been known to have antiviral and antitumoral activities in vivo through activation of immune responses. The present study was set out to define the immunomodulatory activity of acemannan on dendritic cells (DCs), which are the most important accessory cells for the initiation of primary immune responses, Immature DCs were generated from mouse bone marrow (BM) cells by culturing in a medium supplemented with GM-CSF and IL-4. and then stimulated with acemannan, sulfated acemannan. and LPS. respectively. The resultant DCs were examined for phenotypic and functional properties. Phenotypic analysis for the expression of class II MHC molecules and major eo-stimulatory molecules such as B7-1. B7-2. CD40 and CD54 confirmed that acemannan could induce maturation of immature DCs. Functional maturation of immature DCs was supported by increased allogeneic mixed lymphocyte reaction (MLR) and IL-12 production. The differentiation-inducing activity of acemannan was almost completely abolished by chemical sulfation. Based on these results, we propose that the adjuvant activity of acemannan is at least in part due to its capacity to promote differentiation of immature DCs. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/12/17 alle ore 23:38:38