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Titolo:
Biosynthesis of ascorbic acid in plants: A renaissance
Autore:
Smirnoff, N; Conklin, PL; Loewus, FA;
Indirizzi:
Univ Exeter, Sch Biol Sci, Hatherly Labs, Exeter EX4 4PS, Devon, England Univ Exeter Exeter Devon England EX4 4PS , Exeter EX4 4PS, Devon, England Cornell Univ, Boyce Thompson Inst Plant Res, Ithaca, NY 14853 USA Cornell Univ Ithaca NY USA 14853 son Inst Plant Res, Ithaca, NY 14853 USA Washington State Univ, Inst Biol Chem, Pullman, WA 99164 USA Washington State Univ Pullman WA USA 99164 ol Chem, Pullman, WA 99164 USA
Titolo Testata:
ANNUAL REVIEW OF PLANT PHYSIOLOGY AND PLANT MOLECULAR BIOLOGY
, volume: 52, anno: 2001,
pagine: 437 -
SICI:
1040-2519(2001)52:<437:BOAAIP>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-LACTONE DEHYDROGENASE; D-ERYTHROASCORBIC ACID; DEFICIENT ARABIDOPSIS MUTANT; D-MANNOSE PYROPHOSPHORYLASE; D-ARABINOSE DEHYDROGENASE; L-GULONOLACTONE OXIDASE; TRANSGENIC SUGAR-BEET; PHOSPHOMANNOSE ISOMERASE; SACCHAROMYCES-CEREVISIAE; KEY ENZYME;
Keywords:
Arabidopsis thaliana; erythroascorbic acid; fungi; L-galactose; genetics; mannose; oxalate;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
171
Recensione:
Indirizzi per estratti:
Indirizzo: Smirnoff, N Univ Exeter, Sch Biol Sci, Hatherly Labs, Prince Wales Rd, Exeter EX4 4PS,Devon, England Univ Exeter Prince Wales Rd Exeter Devon EnglandEX4 4PS gland
Citazione:
N. Smirnoff et al., "Biosynthesis of ascorbic acid in plants: A renaissance", ANN R PLANT, 52, 2001, pp. 437

Abstract

The structure of the familiar antioxidant L-ascorbic acid (vitamin C) was described in 1933 yet remarkably, its biosynthesis in plants remained elusive until only recently. It became clear from radioisotopic labeling studiesin the 1950s that plant ascorbic acid biosynthesis does not proceed in tote via a route similar to that in mammals. The description in 1996 of an Arabidopsis thaliana mutant deficient in ascorbic acid prompted renewed research effort in this area, and subsequently in 1998 a new pathway was discovered that is backed by strong biochemical and molecular genetic evidence. This pathway proceeds through the intermediates GDP-D-mannose, L-galactose, and L-galactono-1,4-lactone. Much research has focused on the properties of the terminal enzyme responsible for conversion of the aldonolactone to ascorbate, and on related enzymes in both mammals and fungi. Two of the plant biosynthetic genes have been studied at the molecular level and additional ascorbate-deficient A. thaliana mutants may hold the key to other proteins involved in plant ascorbate metabolism. An analysis of the biosynthesis of ascorbate and its analogues in algae and fungi as well as the study of alternative proposed pathways should broaden our understanding of ascorbate metabolism in plants. With a biosynthetic pathway in hand, research on areas such as the control of ascorbate biosynthesis and the physiological roles of ascorbate should progress rapidly.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/10/17 alle ore 11:09:24