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Titolo:
Modifier genes and variation in cystic fibrosis
Autore:
Drumm, ML;
Indirizzi:
Case Western Reserve Univ, Dept Pediat, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Case Western Reserve Univ, Dept Genet, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Case Western Reserve Univ, Inst Human Genet, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA
Titolo Testata:
RESPIRATORY RESEARCH
fascicolo: 3, volume: 2, anno: 2001,
pagine: 125 - 128
SICI:
1465-993X(2001)2:3<125:MGAVIC>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; MANNOSE-BINDING LECTIN; DISEASE SEVERITY; MICE; POLYMORPHISMS; ASSOCIATION; DECLINE;
Keywords:
genetic variation; infection; inflammation; ion transport; pulmonary function;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Drumm, ML Case Western Reserve Univ, Dept Pediat, 830 BRB,10900 euclid Ave, Cleveland, OH 44106 USA Case Western Reserve Univ 830 BRB,10900 euclid Ave Cleveland OH USA 44106
Citazione:
M.L. Drumm, "Modifier genes and variation in cystic fibrosis", RESPIR RES, 2(3), 2001, pp. 125-128

Abstract

The availability of molecular tools to carry out genotyping has led to a flurry of association studies between specific genes and clinical indices ofdisease or disease susceptibility. Human studies, for the most part, have a limited number of subjects available, precluding whole genome types of approaches. 'Candidate gene' strategies have consequently become widespread, probably in part due to the inherent similarity to clinical association studies. Such studies in cystic fibrosis have found tantalizing results in genes involved in infection and inflammation, but many other relevant pathwaysremain untapped. Genome scanning approaches may eventually uncover genes not currently recognized as important to cystic fibrosis. In the meantime, while thousands of polymorphisms are cataloged and other genomic resources become more available, the number of association studies with candidate genes will no doubt increase. To make sense of these studies, the choice of gene and phenotype must be carefully considered.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/10/17 alle ore 11:08:15