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Titolo:
Metabolic substrates other than glucose support axon function in central white matter
Autore:
Brown, AM; Wender, R; Ransom, BR;
Indirizzi:
Univ Washington, Sch Med, Dept Neurol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 , Dept Neurol, Seattle, WA 98195 USA Univ Washington, Sch Med, Dept Physiol & Biophys, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 iol & Biophys, Seattle, WA 98195 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE RESEARCH
fascicolo: 5, volume: 66, anno: 2001,
pagine: 839 - 843
SICI:
0360-4012(200112)66:5<839:MSOTGS>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOUSE-BRAIN; INTRACELLULAR PH; PRIMARY CULTURE; GLIAL-CELLS; RAT; LACTATE; NEURONS; ASTROCYTES; DEPRIVATION; TRANSPORT;
Keywords:
astrocytes; energy metabolism; lactate; pyruvate; glutamate; glutamine; fructose; mannose; rat optic nerve;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Brown, AM Univ Washington, Sch Med, Dept Neurol, Box 356465, Seattle, WA 98195 USA Univ Washington Box 356465 Seattle WA USA 98195 le, WA 98195 USA
Citazione:
A.M. Brown et al., "Metabolic substrates other than glucose support axon function in central white matter", J NEUROSC R, 66(5), 2001, pp. 839-843

Abstract

We tested the hypothesis that non-glucose energy sources can support axon function in the rat optic nerve. Axon function was assessed by monitoring the stimulus-evoked compound action potential (CAP). CAP was maintained at full amplitude for 2 hr in 10 mM glucose. 20 mM lactate, 20 mM pyruvate, 10 mM fructose, or 10 mM mannose supported axon function as effectively as didglucose, and 10 mM glutamine provided partial support, but beta -hydroxybutyrate, octanoate, sorbitol, alanine, aspartate, and glutamate failed to support axon function. Our results indicated that a variety of compounds can sustain function in CNS myelinated axons. Axons probably use lactate, pyruvate, and glutamine directly as energy substrates, whereas mannose and fructose could be shuttled through astrocytes to lactate, which is then exportedto axons. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/10/17 alle ore 11:10:20