Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Multiple lysosomal trafficking phenotypes in metastatic mouse mammary tumor cell lines
Autore:
Tao, K; Li, J; Warner, J; MacLeod, K; Miller, FR; Sahagian, GG;
Indirizzi:
Tufts Univ, Sch Med, Dept Physiol, Boston, MA 02111 USA Tufts Univ BostonMA USA 02111 ch Med, Dept Physiol, Boston, MA 02111 USA Karmanos Canc Inst, Detroit, MI 48201 USA Karmanos Canc Inst Detroit MI USA 48201 Canc Inst, Detroit, MI 48201 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 6, volume: 19, anno: 2001,
pagine: 1333 - 1339
SICI:
1019-6439(200112)19:6<1333:MLTPIM>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-II RECEPTOR; MANNOSE 6-PHOSPHATE RECEPTOR; CATHEPSIN-D; BREAST-CANCER; UROKINASE RECEPTOR; IGF-II; PROTEIN; ACTIVATION; PROLIFERIN; MECHANISM;
Keywords:
lysosome; cathepsins; metastasis; extravasation; lymph nodes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Sahagian, GG Tufts Univ, Sch Med, Dept Physiol, 136 Harrison Ave, Boston, MA 02111 USA Tufts Univ 136 Harrison Ave Boston MA USA 02111 MA 02111 USA
Citazione:
K. Tao et al., "Multiple lysosomal trafficking phenotypes in metastatic mouse mammary tumor cell lines", INT J ONCOL, 19(6), 2001, pp. 1333-1339

Abstract

Although altered synthesis and trafficking of lysosomal proteins and theirreceptors are associated with a wide range of human and rodent malignancies, the basis for their involvement remains obscure. Here we describe findings on a set of mouse mammary tumor cell lines that we are using as a model to study the role of these proteins in oncogenesis and tumor progression. Three distinct proteinase-secreting phenotypes were identified among the metastatic cell lines of the set. Two phenotypes displayed a high level of secretion of cathepsin L and the third was characterized by elevated secretionof matrix metalloproteinase 9 (MMP-9). The two cathepsin L-secreting phenotypes were distinct in that they displayed differences in cathepsin trafficking, expression of mannose 6-phosphate/insulin-like growth factor receptorand expression of proliferin, a mannose-phosphorylated angiogenic factor. Although cells representing all three phenotypes are capable of dissemination to distant organs when implanted into mouse mammary glands, only cells with the MMP-9 phenotype were found to be capable of direct intravasation. These findings indicate that multiple proteinase-secreting phenotypes can arise from the same tumor and suggest that cathepsin L and other lysosomal proteins may play a role in dissemination of tumor cells via the lymphatic system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/12/17 alle ore 23:39:33