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Titolo:
Antidepressants do not modulate estrogen receptor alpha-mediated gene expression
Autore:
Hermann, B; Vollmer, I; Holsboer, F; Rupprecht, R;
Indirizzi:
Max Planck Inst Psychiat, D-8000 Munich, Germany Max Planck Inst PsychiatMunich Germany D-8000 t, D-8000 Munich, Germany
Titolo Testata:
JOURNAL OF NEURAL TRANSMISSION
fascicolo: 10, volume: 108, anno: 2001,
pagine: 1197 - 1202
SICI:
0300-9564(2001)108:10<1197:ADNMER>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-ADRENOCORTICAL SYSTEM; LIGAND-INDEPENDENT ACTIVATION; STEROID-HORMONE RECEPTORS; GLUCOCORTICOID RECEPTOR; MINERALOCORTICOID RECEPTOR; MAMMALIAN-CELLS; DESIPRAMINE; PATHWAY; DNA;
Keywords:
estrogen receptors; antidepressants; gene expression; transcription;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Rupprecht, R Univ Munich, Dept Psychiat, Nussbaumstr 7, D-80336 Munich, Germany Univ Munich Nussbaumstr 7 Munich Germany D-80336 ch, Germany
Citazione:
B. Hermann et al., "Antidepressants do not modulate estrogen receptor alpha-mediated gene expression", J NEURAL TR, 108(10), 2001, pp. 1197-1202

Abstract

The estrogen receptor alpha has been shown to be activated both in a ligand-dependent and in a ligand independent fashion. We investigated whether antidepressants may directly activate the estrogen receptor a or enhance ligand-dependent or ligand-in dependent activation of the estrogen receptor ck. Whereas both ligand-dependent and ligand-independent activation of the estrogen receptor alpha could be demonstrated in transient transfection studies, antidepressants neither directly activated the estrogen receptor alpha nor did they enhance ligand-dependent or ligand-independent activation. Thus, there are differences between the glucocorticoid receptor and the estrogen receptor alpha with regard to ligand-independent activation and action ofantidepressants.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/05/18 alle ore 12:59:22