Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Expression of Notch homologues in the synovium of rheumatoid arthritis andosteoarthritis patients
Autore:
Ishii, H; Nakazawa, M; Yoshino, SI; Nakamura, H; Nishioka, K; Nakajima, T;
Indirizzi:
St Marianna Univ, Sch Med, Inst Med Sci, Dept Genome Sci,Miyamae Ku, Kanagawa 2168512, Japan St Marianna Univ Kanagawa Japan 2168512 amae Ku, Kanagawa 2168512, Japan St Marianna Univ, Sch Med, Inst Med Sci, Rheumatol Immunol & Genet Program, Kanagawa 2168512, Japan St Marianna Univ Kanagawa Japan 2168512 Program, Kanagawa 2168512, Japan Nippon Med Coll, Dept Joint Dis & Rheumatism, Tokyo 1138602, Japan Nippon Med Coll Tokyo Japan 1138602 s & Rheumatism, Tokyo 1138602, Japan
Titolo Testata:
RHEUMATOLOGY INTERNATIONAL
fascicolo: 1, volume: 21, anno: 2001,
pagine: 10 - 14
SICI:
0172-8172(200109)21:1<10:EONHIT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR; CELLS; GENE; ARTHROPATHY; RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Nakajima, T St Marianna Univ, Sch Med, Inst Med Sci, Dept Genome Sci,Miyamae Ku, 2-16-1 Sugao, Kanagawa 2168512, Japan St Marianna Univ 2-16-1 Sugao Kanagawa Japan 2168512 2, Japan
Citazione:
H. Ishii et al., "Expression of Notch homologues in the synovium of rheumatoid arthritis andosteoarthritis patients", RHEUM INTL, 21(1), 2001, pp. 10-14

Abstract

Notch is known as a receptor that controls differentiation or proliferation in various cells and is associated with several diseases. The objective of the present study was to clarify whether human Notch homologues Notch-1, -2, -3, and -4 are expressed in synovium and synoviocytes from rheumatoid arthritis (RA) and osteoarthritis (OA) patients. Immunohistochemical staining showed that Notch-1, -2, and -3 were clearly expressed in the synovium from both RA and OA, whereas Notch-4 was only slightly detected. We further performed Western blotting with the same antibodies used in immunohistochemical staining. Notch-1 and -2 were strongly detected in both RA and OA, and the expression of Notch-3 was slightly detected, while there was no Notch-4expression in both RA and OA synoviocytes. In contrast, all Notch homologues were strongly expressed in the synovium at the developmental stage obtained from the infant. These results indicate that the expression pattern of Notch among synovium from OA and RA patients differed from that of normal subjects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/06/18 alle ore 16:58:27