Catalogo Articoli (Spogli Riviste)
Titolo: Imprinting defects in mouse embryos: Stochastic errors or polymorphic phenotype?
Autore: Croteau, S; Polychronakos, C; Naumova, AK;
- Royal Victoria Hosp, Dept Obstet & Gynecol, Montreal, PQ, Canada Royal Victoria Hosp Montreal PQ Canada t & Gynecol, Montreal, PQ, Canada Montreal Childrens Hosp, Dept Pediat, Montreal, PQ H3H 1P3, Canada Montreal Childrens Hosp Montreal PQ Canada H3H 1P3 al, PQ H3H 1P3, Canada McGill Univ, Ctr Hlth, Res Inst, Dept Human Genet, Montreal, PQ, Canada McGill Univ Montreal PQ Canada t, Dept Human Genet, Montreal, PQ, Canada
- Titolo Testata:
pagine: 11 - 16
- BECKWITH-WIEDEMANN-SYNDROME; DNA METHYLATION; EPIGENETIC MODIFICATION; WILMS-TUMOR; H19 GENE; CANCER; EXPRESSION; RELAXATION; IGF2; DISRUPTION;
- Tipo documento:
- Settore Disciplinare:
- Life Sciences
- Indirizzi per estratti:
- Indirizzo: Naumova, AK Royal Victoria Hosp, Dept Obstet & Gynecol, Womens Pavil,F3-36,Pine Ave W,Montreal, PQ, Canada Royal Victoria Hosp Womens Pavil,F3-36,Pine Ave W Montreal PQ Canada
- S. Croteau et al., "Imprinting defects in mouse embryos: Stochastic errors or polymorphic phenotype?", GENESIS, 31(1), 2001, pp. 11-16
Abstract Defects in expression of imprinted genes are believed to cause developmental abnormalities and play a role in carcinogenesis. To determine whether spontaneous imprinting defects may occur in mouse embryos, we studied the expression of two imprinted genes H19 and Igf2 in individual postimplantation 7.5 d.p.c. and 8.5 d.p.c. embryos. Biallelic expression of H19 was found in1.6% of the embryos, whereas biallelic expression of Igf2 was found in 0.5% of the embryos. The loss of H19 imprinting (LOI) observed in a small fraction of early postimplantation embryos may be purely stochastic. Alternatively, since we never observed it in an inbred background, it may depend on genetic factors acting in trans. Either mechanism could explain the occurrence of polymorphic imprinting as well as the genesis of sporadic imprinting defects, including cancer. The frequency of LOI of H19 was higher than the incidence of sporadic imprinting disorders in humans (about 1 in 20,000). This contradiction may be explained by different incidence of imprinting errors in different imprinted regions of the genome, in different species, or by loss of the majority of nonmosaic embryos with imprinting defects beforebirth. (C) 2001 Wiley-Liss, Inc.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/05/13 alle ore 08:03:29