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Titolo:
The genomics and genetics of human infectious disease susceptibility
Autore:
Hill, AVS;
Indirizzi:
Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England Univ Oxford Oxford England OX3 7BN Human Genet, Oxford OX3 7BN, England
Titolo Testata:
ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS
, volume: 2, anno: 2001,
pagine: 373 - 400
SICI:
1527-8204(2001)2:<373:TGAGOH>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
MANNOSE-BINDING PROTEIN; HEPATITIS-C VIRUS; HUMAN NRAMP1 GENE; D-RECEPTOR GENE; MAJOR HISTOCOMPATIBILITY COMPLEX; CREUTZFELDT-JAKOB-DISEASE; LONG-TERM NONPROGRESSORS; JUVENILE RHEUMATOID-ARTHRITIS; PLASMODIUM-FALCIPARUM MALARIA; CLASS-II ALLELES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
180
Recensione:
Indirizzi per estratti:
Indirizzo: Hill, AVS Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England Univ Oxford Oxford England OX3 7BN et, Oxford OX3 7BN, England
Citazione:
A.V.S. Hill, "The genomics and genetics of human infectious disease susceptibility", ANN REV GEN, 2, 2001, pp. 373-400

Abstract

A genetic basis for interindividual variation in susceptibility to human infectious diseases has been indicated by twin, adoptee, pedigree, and candidate gene studies. This has led to the identification of a small number of strong genetic associations with common variants for malaria, HIV infection, and infectious prion diseases. Numerous other genes have shown less strong associations with these and some other infectious diseases, such as tuberculosis, leprosy, and persistent hepatitis viral infections. Many immunogenetic loci influence susceptibility to several infectious pathogens. Recent genetic linkage analyses of measures of infection as well as of infectious disease, including some genome-wide scans, have found convincing evidence of genetic linkage to chromosomal regions wherein susceptibility genes have yet to be identified. These studies indicate a highly polygenic basis for susceptibility to many common infectious diseases, with some emerging examples of interaction between variants of specific polymorphic host and pathogen genes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/10/17 alle ore 11:07:31