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Titolo: Can we model nitric oxide biotransport? A survey of mathematical models for a simple diatomic molecule with surprisingly complex biological activities
Autore: Buerk, DG;
- Indirizzi:
- Univ Penn, Dept Physiol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 t Physiol, Philadelphia, PA 19104 USA Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 t Bioengn, Philadelphia, PA 19104 USA Univ Penn, Inst Environm Med, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 ironm Med, Philadelphia, PA 19104 USA
- Titolo Testata:
- ANNUAL REVIEW OF BIOMEDICAL ENGINEERING
,
volume: 3,
anno: 2001,
pagine: 109 - 143
- SICI:
- 1523-9829(2001)3:<109:CWMNOB>2.0.ZU;2-2
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- SOLUBLE GUANYLATE-CYCLASE; ELECTRON-PARAMAGNETIC-RESONANCE; LOW-DENSITY LIPOPROTEINS; O-2-HB REACTION-KINETICS; OPTIC-NERVE HEAD; S-NITROSOHEMOGLOBIN; RELAXING FACTOR; BLOOD-FLOW; MITOCHONDRIAL RESPIRATION; XANTHINE-OXIDASE;
- Keywords:
- blood flow; endothelium; mass transport; nitric oxide synthases; nitrosohemoglobins; nitrosothiols; oxygen transport; oxyhemoglobin; peroxynitrite; reaction kinetics; soluble guanylate cyclase;
- Tipo documento:
- Review
- Natura:
- Periodico
- Settore Disciplinare:
- Life Sciences
- Citazioni:
- 119
- Recensione:
- Indirizzi per estratti:
- Indirizzo: Buerk, DG Univ Penn, Dept Physiol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Philadelphia, PA 19104 USA
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- Citazione:
- D.G. Buerk, "Can we model nitric oxide biotransport? A survey of mathematical models for a simple diatomic molecule with surprisingly complex biological activities", ANN REV B E, 3, 2001, pp. 109-143
Abstract
Nitric oxide (NO) is a remarkable free radical gas whose presence in biological systems and whose astonishing breadth of physiological and pathophysiological activities have only recently been recognized. Mathematical modelsfor NO biotransport, just beginning to emerge in the literature, are examined in this review. Some puzzling and paradoxical properties of NO may be understood by modeling proposed mechanisms with known parameters. For example, it is not obvious how NO can survive strong scavenging by hemoglobin andstill be a potent vasodilator. Recent models do not completely explain howtissue NO can reach effective levels in the vascular wall, and they point toward mechanisms that need further investigation. Models help to make sense of extremely low partial pressures of NO exhaled from the lung and may provide diagnostic information. The role of NO as a gaseous neurotransmitter is also being understood through modeling. Studies on the effects of NO on O-2 transport and metabolism, also reviewed, suggest that previous mathematical models of transport of O-2 to tissue need to be revised, taking the biological activity of NO into account.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/05/13 alle ore 00:42:53