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Titolo:
Biochemical markers in the synovial fluid of glenohumeral joints from patients with rotator cuff tear
Autore:
Yoshihara, Y; Hamada, K; Nakajima, T; Kyosuke, FA; Fukuda, H;
Indirizzi:
Natl Def Med Coll, Dept Orthopaed Surg, Tokorozawa, Saitama 3598513, JapanNatl Def Med Coll Tokorozawa Saitama Japan 3598513 Saitama 3598513, Japan Tokai Univ, Sch Med, Dept Orthopaed Surg, Tokai, Ibaraki, Japan Tokai Univ Tokai Ibaraki Japan ept Orthopaed Surg, Tokai, Ibaraki, Japan
Titolo Testata:
JOURNAL OF ORTHOPAEDIC RESEARCH
fascicolo: 4, volume: 19, anno: 2001,
pagine: 573 - 579
SICI:
0736-0266(200107)19:4<573:BMITSF>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SANDWICH ENZYME-IMMUNOASSAY; MATRIX METALLOPROTEINASES; RHEUMATOID-ARTHRITIS; TISSUE INHIBITOR; HYDROXYAPATITE CRYSTALS; PROTEOGLYCAN FRAGMENTS; INTERGLOBULAR DOMAIN; ARTICULAR-CARTILAGE; MILWAUKEE SHOULDER; ACTIVE COLLAGENASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Yoshihara, Y Natl Def Med Coll, Dept Orthopaed Surg, 3-2 Namiki, Tokorozawa, Saitama 3598513, Japan Natl Def Med Coll 3-2 Namiki Tokorozawa Saitama Japan 3598513
Citazione:
Y. Yoshihara et al., "Biochemical markers in the synovial fluid of glenohumeral joints from patients with rotator cuff tear", J ORTHOP R, 19(4), 2001, pp. 573-579

Abstract

It is known that rotator cuff tears are sometimes accompanied by joint destruction. Our purpose was to elucidate the pathology with this condition. Thirty-two synovial fluid (SF) samples aspirated from the glenohumeral joints of patients with rotator cuff tears, including 7 with partial-thickness and 25 with full-thickness tears of the rotator cuff (10 massive and 15 isolated supraspinatus tendon (SSp) tears), were examined. Collagenase (MMP-1),stromelysin 1 (MMP-3), tissue inhibitor of metalloproteinases-1 (TIMP-1) and carboxy-terminal type II procollagen peptide (pCOL II-C) were measured in the SF using the respective sandwich enzyme immunoassays. Glycosaminoglycan (GAG) was also quantified with a cationic dye binding method using 1,9-dimethylmethylene blue. Levels of any molecules except pCOL II-C in the SF appeared to be higher in full-thickness tears than those in partial-thickness tears. Moreover, levels of MMP-1, MMP-3 and GAG in the SF were significantly higher in massive tears of the rotator cuff in comparison with those inisolated SSp tears. Such significance was not observed in the levels of TIMP-1 or pCOL II C in the SF. We examined the relation of those levels with operative findings or clinical parameters from full-thickness tears, and observed significant correlations of the tear size with the levels of MMP-1, MMP-3 and GAG in the SF. Although these marker molecules in SF do not always originate from cartilage, our results may indicate the potential for accelerated cartilage-degrading activity in the glenohumeral joint in massive tears of the rotator cuff. (C) 2001 Orthopaedic Research Society. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/06/18 alle ore 17:06:03