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Titolo: Human leukocyte antigen gene polymorphism and the histocompatibility laboratory
Autore: Williams, TM;
- Indirizzi:
- Univ New Mexico, Hlth Sci Ctr, Dept Pathol, Albuquerque, NM 87131 USA UnivNew Mexico Albuquerque NM USA 87131 athol, Albuquerque, NM 87131 USA
- Titolo Testata:
- JOURNAL OF MOLECULAR DIAGNOSTICS
fascicolo: 3,
volume: 3,
anno: 2001,
pagine: 98 - 104
- SICI:
- 1525-1578(200108)3:3<98:HLAGPA>2.0.ZU;2-C
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- MARROW-DONOR-PROGRAM; HLA-DR; UNRELATED DONOR; CLASS-I; TRANSPLANTATION; ALLELES;
- Tipo documento:
- Review
- Natura:
- Periodico
- Settore Disciplinare:
- Clinical Medicine
- Citazioni:
- 32
- Recensione:
- Indirizzi per estratti:
- Indirizzo: Williams, TM Univ New Mexico, Hlth Sci Ctr, Dept Pathol, Room 337-BMSB,915Camino de Salud SE, Albuquerque, NM 87131 USA Univ New Mexico Room 337-BMSB,915 Camino de Salud SE Albuquerque NM USA 87131
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- Citazione:
- T.M. Williams, "Human leukocyte antigen gene polymorphism and the histocompatibility laboratory", J MOL DIAGN, 3(3), 2001, pp. 98-104
Abstract
The human leukocyte antigens (HLA) encoded by genes within the major histocompatibility complex display an impressive degree of polymorphism. This variability is apparently maintained in human populations through the need tosuccessfully display a wide range of processed foreign peptides to the T cell antigen receptor. The large number of alleles at the Class I and Class II loci pose a significant problem for molecular diagnosis. Knowledge of allele groups and specific alleles present in individuals has important implications in organ and stem cell transplantation and in disease association studies. Histocompatibility laboratories have transformed themselves during the past decade as they have adapted the techniques of molecular diagnostics to the challenge of identifying HLA alleles.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/06/13 alle ore 07:55:59