Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Major histocompatibility complex class I-recognizing receptors are diseaserisk genes in rheumatoid arthritis
Autore:
Yen, JH; Moore, BE; Nakajima, T; Scholl, D; Schaid, DJ; Weyand, CM; Goronzy, JJ;
Indirizzi:
Mayo Clin, Dept Med, Rochester, MN 55905 USA Mayo Clin Rochester MN USA 55905 Clin, Dept Med, Rochester, MN 55905 USA Mayo Clin, Dept Immunol, Rochester, MN 55905 USA Mayo Clin Rochester MN USA 55905 n, Dept Immunol, Rochester, MN 55905 USA Mayo Clin, Dept Hlth Sci Res, Rochester, MN 55905 USA Mayo Clin RochesterMN USA 55905 pt Hlth Sci Res, Rochester, MN 55905 USA
Titolo Testata:
JOURNAL OF EXPERIMENTAL MEDICINE
fascicolo: 10, volume: 193, anno: 2001,
pagine: 1159 - 1167
SICI:
0022-1007(20010521)193:10<1159:MHCCIR>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; HLA-C; T-CELLS; INHIBITORY RECEPTORS; COSTIMULATORY MOLECULES; FUNCTIONAL TRANSFER; DIRECT BINDING; AMINO-ACID; RECOGNITION; SUSCEPTIBILITY;
Keywords:
killer cell immunoglobulin-like receptor; T cell; genetic susceptibility; rheumatoid arthritis; vasculitis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Goronzy, JJ Mayo Clin, Dept Med, Guggenheim 401,200 1st St SW, Rochester, MN 55905 USA Mayo Clin Guggenheim 401,200 1st St SW Rochester MN USA 55905
Citazione:
J.H. Yen et al., "Major histocompatibility complex class I-recognizing receptors are diseaserisk genes in rheumatoid arthritis", J EXP MED, 193(10), 2001, pp. 1159-1167

Abstract

Rheumatoid arthritis JRA) is a heterogeneous syndrome of which a subset ofpatients develops vascular inflammation. The genetic determinants that confer risk for rheumatoid vasculitis are not known, but patients with vascular complications are known to have an expansion of CD4(+)CD28(null) T cells,a cell population potentially involved in endothelial damage. CD4(+)CD28(null) T cell clones isolated from RA patients with vasculitis were found to express killer cell immunoglobulin-like receptors (KIRs) with the stimulatory KIR2DS3 often present in the absence of opposing inhibitory receptors with related specificities. To test the hypothesis that the KIR2DS2, gene is involved in the development of vasculitis, association studies were performed. The KIR2DS2 gene was significantly enriched among patients with rheumatoid vasculitis compared with normal individuals (odds ratio 5.56, P = 0.001) and patients with KA but no vasculitis (odds ratio 7.96, P = 0.001). Also, the distribution of human histocompatibility leukocyte antigen (HLA)-C, the putative ligand for KIRs, was significantly different in patients with rheumatoid vasculitis in comparison with the control populations. These datasuggest that HLA class I-recognizing receptors and HLA class I genes are genetic risk determinants that modulate the pattern of KA expression. Specifically, KIR2DS3 in conjunction with the appropriate HLA-C ligand may have arole in vascular damage by regulating CD4(+)CD28(null) T cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/06/18 alle ore 17:33:20