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Titolo:
Development of an enhanced anticaries efficacy dual component dentifrice containing sodium fluoride and dicalcium phosphate dihydrate
Autore:
Sullivan, RJ; Masters, J; Cantore, R; Roberson, A; Petrou, I; Stranick, M; Goldman, H; Guggenheim, B; Gaffar, A;
Indirizzi:
Colgate Palmolive Co, Oral Care Adv Technol Dept, Piscataway, NJ 08855 USAColgate Palmolive Co Piscataway NJ USA 08855 pt, Piscataway, NJ 08855 USA Colgate Palmolive Co, Oral Care Prod Dev Dept, Piscataway, NJ 08855 USA Colgate Palmolive Co Piscataway NJ USA 08855 pt, Piscataway, NJ 08855 USA Colgate Palmolive Co, Measurement Sci Dept, Piscataway, NJ 08855 USA Colgate Palmolive Co Piscataway NJ USA 08855 pt, Piscataway, NJ 08855 USA Colgate Palmolive Co, Growth Technol Dev, Piscataway, NJ 08855 USA ColgatePalmolive Co Piscataway NJ USA 08855 ev, Piscataway, NJ 08855 USA
Titolo Testata:
AMERICAN JOURNAL OF DENTISTRY
, volume: 14, anno: 2001,
pagine: 3A - 11A
SICI:
0894-8275(200105)14:<3A:DOAEAE>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEMINERALIZATION IN-VITRO; PLAQUE FLUID; ENAMEL DEMINERALIZATION; CARIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Sullivan, RJ Colgate Palmolive Co, Oral Care Adv Technol Dept, Piscataway,NJ 08855 USA Colgate Palmolive Co Piscataway NJ USA 08855 y, NJ 08855 USA
Citazione:
R.J. Sullivan et al., "Development of an enhanced anticaries efficacy dual component dentifrice containing sodium fluoride and dicalcium phosphate dihydrate", AM J DENT, 14, 2001, pp. 3A-11A

Abstract

A dual-chamber dentifrice, which contains sodium fluoride (NaF) in one component and dicalcium phosphate dihydrate (dical) in the other, has been developed. The dentifrice is packaged in a dual-chamber tube and is formulatedto deliver 1100 ppm F. A series of studies consisting of in vitro fluorideuptake, in vivo calcium labeling, intraoral remineralization-demineralization, and animal caries studies were performed to support the improved anticaries efficacy of this product in comparison to a sodium fluoride/silica dentifrice (NaF/silica). An in vitro fluoride uptake study comparing 1100 ppmF NaF/dical dentifrice to 1100 ppm F NaF/silica showed that NaF/dical delivered significantly more fluoride than NaF/silica, 3.72 +/- 0.36 mug/cm(2) versus 2.41 +/- 0.10 mug/cm(2). A 6-day in vivo brushing study with a Ca-44labeled NaF/dical dentifrice showed that calcium from dical penetrated demineralized enamel and was present in plaque up to 18 hrs since the last brushing. An intra-oral remineralization-demineralization study was performed to evaluate NaF/dical's ability to promote remineralization in comparison to three silica-based dentifrices containing 0, 250, and 1100 ppm F as NaF. The percent mineral changes after treatment were +20.44 +/- 17.14 for NaF/dical, +9.27 +/- 19.53 for 1100 ppm NaF/silica, -1.43 +/- 20.57 for 250 ppm NaF/silica, and -12.36 +/- 32.76 for 0 ppm F/silica. A statistical analysisshowed that the dual-chamber NaF/dical dentifrice was significantly more effective than the 1100 ppm NaF/silica dentifrice at promoting remineralization. A rat caries study was performed to evaluate NaF/dical ability to prevent caries in comparison to 1100 ppm F NaF/silica, 250 ppm F NaFisilica, silica, and dical dentifrices. The mean smooth surface caries scores were 1.6+/- 2.8 for NaF/dical, 5.5 +/- 6.2 for 1100 ppm F NaF/silica, 10.6 +/- 6.2for 250 ppm (N) over dot F/silica, 13.7 +/- 4.7 for 0 ppm F/silica, and 9.5 +/- 7.8 0 ppm F/dical. A statistical analysis showed that the the dual-chamber NaF/dical dentifrice was superior to all other treatments tested in preventing caries in rats. The dical dentifrice was significantly superior to the silica dentifrice in preventing caries, which indicates that dical alone exhibits anticaries efficacy. In conclusion, individual and cumulative results from the fluoride uptake, intra-oral remineralization-demineralization, and rat caries studies from the dual chamber NaF/dical dentifrice support the improved anticaries efficacy of this product.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/06/18 alle ore 17:03:25