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Titolo: Histamine utilizes JAK-STAT pathway in regulating cytokine production
Autore: Osna, N; Elliott, K; Chaika, O; Patterson, E; Lewis, RE; Khan, MM;
- Indirizzi:
- Creighton Univ, Dept Pharmaceut & Adm Sci, Omaha, NE 68178 USA Creighton Univ Omaha NE USA 68178 armaceut & Adm Sci, Omaha, NE 68178 USA Univ Nebraska, Med Ctr, Eppley Inst Res Canc & Allied Dis, Omaha, NE 68198USA Univ Nebraska Omaha NE USA 68198 es Canc & Allied Dis, Omaha, NE 68198USA Creighton Univ, Dept Biomed Sci, Omaha, NE 68178 USA Creighton Univ OmahaNE USA 68178 v, Dept Biomed Sci, Omaha, NE 68178 USA
- Titolo Testata:
- INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 4,
volume: 1,
anno: 2001,
pagine: 759 - 762
- SICI:
- 1567-5769(200104)1:4<759:HUJPIR>2.0.ZU;2-Z
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- PROTEIN-KINASE-A; INTERFERON-GAMMA; SIGNAL-TRANSDUCTION; EXPRESSION; INTERLEUKIN-2; ACTIVATION;
- Keywords:
- histamine; JAK-STAT; cytokine;
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Life Sciences
- Citazioni:
- 12
- Recensione:
- Indirizzi per estratti:
- Indirizzo: Khan, MM Creighton Univ, Dept Pharmaceut & Adm Sci, Omaha, NE 68178 USA Creighton Univ Omaha NE USA 68178 & Adm Sci, Omaha, NE 68178 USA
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- Citazione:
- N. Osna et al., "Histamine utilizes JAK-STAT pathway in regulating cytokine production", INT IMMUNO, 1(4), 2001, pp. 759-762
Abstract
Histamine shifts TH1/TH7 cytokine balance from TH1 to TH2 cytokines. The phosphorylation of STAT factors and their translocation to nucleus are important steps in the regulation of TH1/TH2 cytokine balance. This study was designed to investigate the effects of histamine on Janus kinases-signal transducers and activators of transcription (JAK-STAT) pathway. The splenocyteswere treated with histamine in the presence or absence of JAK-STAT inhibitor, tyrphostin. activated with IFN gamma for 30 min, and phosphorylated STAT1 was detected by immunoblotting. We found that histamine up-regulated thephosphorylation of STAT1 and tyrphostin prevented this phosphorylation. Wethen studied the effects of tyrphostin on histamine-mediated inhibition ofIFN gamma production and histamine-mediated stimulation of IL-5 and IL-10 production. Tyrphostin dose-dependently reversed the effects of histamine on IFN gamma, IL-5 and IL-10 production. as evident by ELISA. These observations suggest that histamine regulated JAK-STAT signal transduction, which is involved in cytokine secretion. (C) 2001 Elsevier Science B.V. All rightsreserved.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/05/13 alle ore 04:21:15