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Titolo:
Two approaches to alpha,alpha-bis-Mannich salts of N-monosubstituted amides
Autore:
Brunschweiger, A; Heber, D;
Indirizzi:
Univ Kiel, Dept Pharmaceut Chem, D-24118 Kiel, Germany Univ Kiel Kiel Germany D-24118 pt Pharmaceut Chem, D-24118 Kiel, Germany
Titolo Testata:
TETRAHEDRON LETTERS
fascicolo: 14, volume: 42, anno: 2001,
pagine: 2653 - 2655
SICI:
0040-4039(20010402)42:14<2653:TATASO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ONE-POT SYNTHESIS; BASES;
Keywords:
amides; ketoximes; bis-dimethylaminomethylacetamides; Mannich reaction; Beckmann rearrangement;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Heber, D Univ Kiel, Dept Pharmaceut Chem, Gutenbergstr 76, D-24118 Kiel, Germany Univ Kiel Gutenbergstr 76 Kiel Germany D-24118 118 Kiel, Germany
Citazione:
A. Brunschweiger e D. Heber, "Two approaches to alpha,alpha-bis-Mannich salts of N-monosubstituted amides", TETRAHEDR L, 42(14), 2001, pp. 2653-2655

Abstract

Two generally applicable syntheses of 2-bis-(dimethylaminomethyl)acetamides 9 are described. The first one involves reaction of N-mono substituted acetamides 3 with dimethyl(methylene)ammonium chloride in the presence of phosphorus oxychloride using diethyl ether as a solvent. Starting from ketoximes, the amines 9 are obtained under the same reaction conditions via Beckmann rearrangement. C-Aminomethylation observed in all cases may be the result of the formation of imidoyl chlorides 5 as intermediates. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/11/17 alle ore 05:52:27