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Titolo:
Inhibitory effect of baicalein, a flavonoid in Scutellaria root, on eotaxin production by human dermal fibroblasts
Autore:
Nakajima, T; Imanishi, M; Yamamoto, K; Cyong, JC; Hirai, K;
Indirizzi:
Univ Tokyo, Grad Sch Med, Dept Bioregulatory Funct, Bunkyo Ku, Tokyo 1138655, Japan Univ Tokyo Tokyo Japan 1138655 ry Funct, Bunkyo Ku, Tokyo 1138655, Japan Univ Tokyo, Grad Sch Med, Dept Allergy & Rheumatol, Tokyo 1138655, Japan Univ Tokyo Tokyo Japan 1138655 Allergy & Rheumatol, Tokyo 1138655, Japan
Titolo Testata:
PLANTA MEDICA
fascicolo: 2, volume: 67, anno: 2001,
pagine: 132 - 135
SICI:
0032-0943(200103)67:2<132:IEOBAF>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VITRO; EOSINOPHILS; CHEMOKINE; BASOPHILS; DAMAGE;
Keywords:
baicalein; eotaxin; Scutellaria Root; chemokine; saiboku-to; flavonoid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Hirai, K Univ Tokyo, Grad Sch Med, Dept Bioregulatory Funct, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan Univ Tokyo 7-3-1 Hongo Tokyo Japan 1138655 Tokyo 1138655, Japan
Citazione:
T. Nakajima et al., "Inhibitory effect of baicalein, a flavonoid in Scutellaria root, on eotaxin production by human dermal fibroblasts", PLANTA MED, 67(2), 2001, pp. 132-135

Abstract

Eotaxin is an eosinophil-specific chemokine associated with the recruitment of eosinophils to sites of allergic inflammation. "Saiboku-to" (Formula magnoliae et bupleuri) is a kampo herbal medicine used for the treatment of bronchial asthma in japan. In this study, we investigated the effects of Scutellaria Root, a major herb in Saiboku-to and its components such as baicalein and baicalin an eotaxin production by IL-4 plus TNF-alpha -stimulated human fibroblasts. An extract of Scutellaria Root markedly inhibited eotaxin production. Four major flavonoids from Scutellaria Root were found to show inhibitory activity on eotaxin production at a concentration of 10 mug/mlin the order of baicalein > oroxylin A > baicalin > skullcapflavon II. Theinhibitory effect of baicalein was expressed in a dose-dependent manner, and almost 50% inhibition was observed at 1.8 mug/ml. Furthermore, baicaleinprevented human eotaxin mRNA expression in IL-4 plus TNF-alpha -stimulatedhuman fibroblasts, These results help explain the pharmacological efficacyof Scutellaria Root in the treatment of bronchial asthma since it would suppress eotaxin associated recruitment of eosinophils.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/06/18 alle ore 17:33:56